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Table 1 Physiologic data a,b

From: Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis

 

VH

BIL

CsA

Bil + CsA

N

5

5

5

5

Body weight (g)

356.5 ± 29.0

356.1 ± 57.6

318.3 ± 57.6

290.6 ± 10.11

SBP (mmHg)

127.5 ± 14.0

139.8 ± 10.0

149.0 ± 19.8

134.0 ± 15.9

Serum creatinine (mg/dL)

0.7 ± 0.1

0.7 ± 0.2

1.7 ± 0.9*†

1.7 ± 0.3*†

24 hr urine albumin (mg)

5.4 ± 4.1

4.8 ± 5.1

9.1 ± 6.5

6.6 ± 3.0

Serum CsA (μg/mL)

0.02 ± 0.00

0.02 ± 0.00

2.89 ± 0.29*†

3.31 ± 0.40*†

Serum LDH (IU/L)

486.6 ± 183.8

623.4 ± 400.1

748.2 ± 182.6

642.2 ± 193.6

Serum AST (IU/L)

79.7 ± 18.9

86.2 ± 41.1

61.6 ± 6.1

66.0 ± 7.0

Serum ALT (IU/L)

29.3 ± 3.8

34.0 ± 17.4

26.4 ± 3.6

31.0 ± 3.3

Serum bilirubin (mg/dL)

0.03 ± 0.03

0.01 ± 0.02

0.16 ± 0.04*†

00.20 ± 0.06*†

  1. aVehicle (VH): The rats received a subcutaneous (SC) injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of DMSO; Bilirubin (BIL): The rats received a SC injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; cyclosporine (CsA): The rats received a SC injection of CsA 15 mg/kg/day plus a intraperitoneal injection of DMSO; BIL + CsA: The rats received a SC injection of CsA 15 mg/kg/day plus a a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; SBP, systolic blood pressure, LDH, lactate dehydrogenase.
  2. bData are displayed as means ± SD.
  3. *P < 0.05 vs. VH, †P < 0.05 vs. Bil, and ‡P < 0.05 vs. CsA.