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Table 1 Physiologic data a,b

From: Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis

  VH BIL CsA Bil + CsA
N 5 5 5 5
Body weight (g) 356.5 ± 29.0 356.1 ± 57.6 318.3 ± 57.6 290.6 ± 10.11
SBP (mmHg) 127.5 ± 14.0 139.8 ± 10.0 149.0 ± 19.8 134.0 ± 15.9
Serum creatinine (mg/dL) 0.7 ± 0.1 0.7 ± 0.2 1.7 ± 0.9*† 1.7 ± 0.3*†
24 hr urine albumin (mg) 5.4 ± 4.1 4.8 ± 5.1 9.1 ± 6.5 6.6 ± 3.0
Serum CsA (μg/mL) 0.02 ± 0.00 0.02 ± 0.00 2.89 ± 0.29*† 3.31 ± 0.40*†
Serum LDH (IU/L) 486.6 ± 183.8 623.4 ± 400.1 748.2 ± 182.6 642.2 ± 193.6
Serum AST (IU/L) 79.7 ± 18.9 86.2 ± 41.1 61.6 ± 6.1 66.0 ± 7.0
Serum ALT (IU/L) 29.3 ± 3.8 34.0 ± 17.4 26.4 ± 3.6 31.0 ± 3.3
Serum bilirubin (mg/dL) 0.03 ± 0.03 0.01 ± 0.02 0.16 ± 0.04*† 00.20 ± 0.06*†
  1. aVehicle (VH): The rats received a subcutaneous (SC) injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of DMSO; Bilirubin (BIL): The rats received a SC injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; cyclosporine (CsA): The rats received a SC injection of CsA 15 mg/kg/day plus a intraperitoneal injection of DMSO; BIL + CsA: The rats received a SC injection of CsA 15 mg/kg/day plus a a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; SBP, systolic blood pressure, LDH, lactate dehydrogenase.
  2. bData are displayed as means ± SD.
  3. *P < 0.05 vs. VH, †P < 0.05 vs. Bil, and ‡P < 0.05 vs. CsA.