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Figure 3 | BMC Nephrology

Figure 3

From: A novel model of adenine-induced tubulointerstitial nephropathy in mice

Figure 3

Histological analyses of kidneys, parathyroid glands and bones. A: Renal histology showed deposition of symmetric crystalline structures in a tubular lumen (arrow A), micro abscesses (B) and dilated tubules (C). PAS staining showed dilated Bowman’s space (D), atrophic tubuli with protein casts (“thyroidization”) (E) and tubular atrophy with thickening of the tubular basement membrane (F). Ladewig staining revealed a mild interstitial fibrosis (G). Extensive calcification of tubular structures (H) was seen with von Kossa staining. B: Parathyroid glands were not hypertrophic but had a significantly increased proliferation rate determined by Ki67 index (8.7 ± 0.7% vs 2.3 ± 0.5%; p < 0.0001). C: In bone, there was an increased number and thickness of submetaphyseal bone trabeculae (arrow A) and increased adipocyte content in the bone marrow (B).

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