Skip to main content

Table 6 Logistic regression model for renal replacement therapy in critically ill H1N1 patients

From: Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study

Variable

RRT

No RRT

Crude OR

P value

Adjusted OR

P value

n = 85

n = 476

(95% CI)

(95% CI)

Demographics and comorbidities

Age (yr)

46.2 (13.1)

48.4 (15.3)

0.99 (0.98-1.01)

0.21

0.98 (0.96-1.00)

0.07

Female sex

43 (50.6)

256 (53.8)

0.88 (0.55-1.40)

0.59

1.81 (0.91-3.58)

0.09

Ethnicity (n = 554, 85, 469)

 White/Caucasian (reference)

56 (65.9)

271 (57.8)

1.00

 

1.00

 

 Unknown/Other

19 (22.4)

97 (20.7)

0.95 (0.54-1.68)

0.85

0.53 (0.22-1.28)

0.16

 Aboriginal

6 (7.1)

68 (14.5)

0.43 (0.18-1.03)

0.06

0.40 (0.13-1.20)

0.10

 Asian

4 (4.7)

33 (7.0)

0.59 (0.20-1.7)

0.33

1.11 (0.31-3.95)

0.88

Obesity

33 (38.8)

117 (24.6)

1.95 (1.20-3.16)

0.007

2.25 (1.14-4.44)

0.02

Diabetes mellitus

23 (27.1)

123 (25.8)

1.06 (0.63-1.79)

0.81

  

Chronic obstructive pulmonary disease

5 (5.9)

93 (19.5)

0.26 (0.10-0.65)

0.004

0.26 (0.06-1.20)

0.08

Alcohol abuse

10 (11.8)

64 (13.5)

0.86 (0.42-1.75)

0.67

  

Chronic kidney disease

15 (17.7)

33 (6.9)

2.88 (1.49-5.57)

0.002

0.85 (0.28-2.57)

0.78

Day 1 support, physiology, and laboratory values

APACHE II score (n = 507, 80, 427)

27.6 (9.2)

19.8 (8.6)

1.10 (1.07-1.13)

<0.0001

1.07 (1.03-1.12)

0.0009

Invasive mechanical ventilation (n = 552, 85, 467)

72 (84.7)

311 (66.6)

2.78 (1.49-5.17)

0.001

4.09 (1.21-13.84)

0.02

Inotrope or vasopressor

44 (51.8)

206 (43.3)

1.41 (0.89-2.23)

0.15

0.78 (0.37-1.61)

0.50

Mean arterial pressure (mmHg) (n = 521, 79, 442)

70.4 (16.9)

75.2 (19.2)

0.87 (0.76-0.995)

0.04

0.97 (0.81–1.16)

0.75

PaO2/FiO2 (n = 495, 76, 419)

132 (95)

156 (96)

0.97 (0.94-1.00)

0.046

0.97 (0.93-1.01)

0.16

Platelets (109/L) (n = 519, 76, 443)

164 (84)

192 (96)

0.97 (0.94-0.995)

0.02

0.99 (0.95-1.03)

0.64

Creatinine (μmol/L) (n = 536, 79, 457)

233 (185)

105 (93)

1.07 (1.05-1.09)

<0.0001

1.06 (1.03-1.10)

<0.0001

  1. Categorical data are presented as n (%) and continuous data as mean (SD). Heart rate, temperature, creatine kinase, WBC, albumin, urea, and urine output were excluded due to a high proportion of missing data. SOFA score was excluded because it was highly collinear with APACHE II (Pearson r = 0.6). For each variable, we specify n when it differs from the totals in the first row. The final model included 411 patients and did not have evidence of lack of goodness of fit (p = 0.17). ORs for continuous variables refer to an increment of 1 unit (age, APACHE II), 10 units (mean arterial pressure, PaO2/FiO2, platelets, creatinine), or 100 units (urine output).
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us