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Table 4 Changes of laboratory and echocardiographic parameters during the follow-up period

From: Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease – a prospective observational study

Parameter

Baseline

After 18 months ± 5

After 36 months ± 10

p value for Baseline vs. 18 months assessment

p value for 18 months assessment vs. 36 months assessment

p value for Baseline vs. 36 assessment

eGFR (MDRD) (ml/s)

0.6

0.57

0.49

p < 0.01

p < 0.05

p < 0.01

(0.25-1.6)

(0.25-1.3)

(0.26-2.8)

   

Haemoglobin (g/l)

128.5 ± 20.0

128.8 ± 20.7

124.3 ± 18.8

p < 0.01

p < 0.01

NS

Serum Phosphate (mmol/l)

1.10

1.16

1.20

NS

NS

NS

(1.00-1.29)

(1.00-1.45)

(1.00-1.36)

   

Parathyroid hormone (pg/ml)

5.96

6.34

7.52

NS

NS

NS

(3.56-9.22)

(4.56-11.98)

(3.63-15.59)

   

25OH Vitamin D (ng/ml)

23.47 ±8.91

25.04 ±9.61

20.87 ±7.79

NS

p < 0.01

p < 0.02

FGF23 (RU/ml)

89.6

100.1

127.0

p < 0.01

p < 0.05

p < 0.0001

(64.8-167.1)

(73.0-228.8)

(78.3-282.4)

   

PAPP-A (mIU/l)

8.3

8.7

9.3

NS

NS

NS

(7.0-10.2)

(7.6-10.5)

(7.5-12.6)

   

sRAGE (pg/ml)

976.3

919.1

1040.7

NS

NS

NS

(720.6-1495.2)

(643.9-1336.3)

(719.1-1375.1)

   

EN-RAGE (ng/ml)

160.5

255.2

269.8

p < 0.05

NS

p < 0.001

(100.5-240.3)

(164.6-297.0)

(163.0-326.3)

   

PlGF (pg/ml)

10.80

11.05

12.5

p < 0.02

NS

NS

(7.8-14.2)

(8.5-15.6)

(8.5-14.7)

   

MMP-2 (ng/ml)

214.5 ±50.6

206.5 ±39.2

221.9 ±61.6

NS

NS

NS

Troponin I (ng/ml)

0.01

0.01

0.01

NS

NS

NS

(0.01-0.01)

(0.01-0.01)

(0.01-0.01)

   

BNP (pg/ml)

30.0

57.0

77.0

p < 0.01

NS

p < 0.0001

(15.0-91.0)

(27.8-107.3)

(40.0-195.0)

   

Left ventricle mass index (g/m 2.7 )

43.6 ± 14.6

45.3 ± 16.0

45.7 ± 13.4

NS

NS

p < 0.05

Left ventricle EF (%)

64.7 ± 7.8

64.5 ± 5.8

62.7 ± 8.0

p < 0.05

NS

p < 0.05

Left atrial diameter (cm/m 2 )

2.14 ± 0.64

2.05 ± 0.55

2.19 ± 0.50

NS

NS

p < 0.01

E/A ratio

0.83

0.83

0.81

NS

NS

NS

 

(0.67 - 1.14)

(0.69 - 0.98)

(0.72-1.04)

   
  1. Arithmetic mean ± SD or median (Interquartile Range).
  2. Comparison: Paired samples t-test for normal distributions, resp. Wilcoxon test for skewed distrubutions.
  3. Abbreviations: BNP brain natriuretic peptide, BSA body surface area, E/A ratio Ratio between early (E) and late (atrial - A) ventricular filling velocity eGFR: estimated glomerular filtration rate, EN-RAGE Extracellular newly identified RAGE-binding protein, FGF23 fibroblast growth factor 23, MDRD modification of diet in renal disease, MMP-2 matrix-metaloproteinase 2, PAPP-A pregnancy associated protein A, PlGF placental growth factor.
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BMC Nephrology

ISSN: 1471-2369

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