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Table 4 Laboratory values in patients with pre-OLT renal dysfunction associated with recovery of renal function post-OLT

From: Predictors of renal recovery in patients with pre-orthotopic liver transplant (OLT) renal dysfunction

 

Recovery of renal function(n = 863)

Non-recovery (n = 857)

p

SCr at time of registration (mg/dL)*

2.4 ± 2.0

2.9 ± 2.6

0.00001

SCr at time of registration (mg/dL)

   

  (adjusted for dialysis, SCr = 4 mg/dL)*

2.5 ± 1.6

2.4 ± 1.7

0.23

SCr at time of registration (mg/dL)

   

  (adjusted for dialysis, SCr = 5 mg/dL)*

2.8 ± 2.0

2.78 ± 2.0

0.30

SCr at time of transplant

3.6 ± 2.0

4.0 ± 2.3

0.00001

SCr at time of transplant (mg/dL)

   

  (adjusted for dialysis, SCr = 4 mg/dL)

3.84 ± 1.5

3.8 ± 1.4

0.52

SCr at time of transplant (mg/dL)

   

  (adjusted for dialysis, SCr = 5 mg/dL)

4.3 ± 1.6

4.3 ± 1.6

0.80

eGFR at time of registration (cc/min)

57 ± 41

50 ± 42

0.00001

eGFR at time of registration (cc/min)

   

  (adjusted for dialysis, SCr = 4 mg/dL)

51 ± 42

53 ± 44

0.33

eGFR at time of registration (cc/min)

   

  (adjusted for dialysis SCr = 5 mg/dL)

51 ± 43

53 ± 46

0.33

eGFR at time of transplant (cc/min)

28 ± 21

22 ± 14

0.00001

eGFR at time of transplant (cc/min)

   

  (adjusted for dialysis, SCr = 4 mg/dL)

20 ± 14

21 ± 12

0.30

eGFR at time of transplant (cc/min)

   

  (adjusted for dialysis, SCr = 5 mg)

19 ± 14

19 ± 12

0.49

Serum ALT at time of transplant (units/L)

257 ± 888

489 ± 1379

0.007

INR at time of transplant

2.1 ± 1.5

2.2 ± 2.8

0.80

Total bilirubin at time of transplant (mg/dL)

14.0 ± 14.4

16.0 ± 16.0

0.38

Serum albumin at time of transplant (g/dL)

2.78 ± 0.76

2.82 ± 0.77

0.18

  1. * For patients receiving RRT, several values of SCr were used, an unadjusted and two adjusted values. The unadjusted SCr was the value entered into the UNOS database. Given uncertainty whether the entered SCr was obtained pre- or post-dialysis, analysis was repeated using a single adjusted value for SCr of either 4.0 or 5.0 mg/dL.
  2. Abbreviations: ALT alanine transaminase, eGFR estimated glomerular filtration rate, INR international normalized ratio, OLT orthotopic liver transplantation, SCr serum creatinine.