Fatty acid metabolism. Linoleic acid is metabolized by 5-LOX to 9-HODE, and by 15-LOX to 13-HODE. Arachidonic acid can be metabolized by COX enzymes to prostaglandins; through 5-LOX and 12/15-LOX enzymes into 4-series leukotrienes (LK) and HETE compounds: 5-HETE, 12-HETE, 15-HETE, 11-HETE, 9-HETE and 8-HETE; and by cytochrome P450 enzymes to HETEs including 20-HETE. Eicosapentaenoic acid is metabolized to HEPE compounds, mainly 5-HEPE, 12-HEPE and 15-HEPE. Docosahexanoic acid can be metabolized by 15-LOX to 17(S)HDHA.