Figure 4

Changes in pro-inflammatory arachidonic acid metabolites (A) 5-HETE, LtB4 and 15-HETE and (B) potentially anti-inflammatory eicosapentaenoic acid metabolites 12-HEPE, 15-HEPE and (C) 5-HEPE in plasma of healthy (+/+) and cystic Cy/+ rats. Cy/+ rats were additionally treated with 4 mg/kg/day lovastatin for 5 weeks. Significance levels are given for Cy/+ control versus +/+ control and Cy/+ plus lovastatin versus Cy/+ control: *p < 0.05 vs. Cy/+ plus lovastatin, **p < 0.01 vs. +/+; n = 5-15.