Table 3 Assessment of exercise tolerance (cardiopulmonary exercise test and six-minute walk test)

Cardiopulmonary test

RPmax (W/kg)

4.9 ± 1.3

3.7 ± 0.9^a

3.0 ± 1.2^a

3.2 ± 1.0^a

0.007

VO₂peak (mL/kg/min)

28.9 ± 7.8

23.3 ± 5.6

21.4 ± 5.2^a

20.2 ± 6.9^a

0.033

VO₂peak (%)

85.4 ± 18.2

75.8 ± 18.3

65.9 ± 16.0^a

63.4 ± 16.0^a

0.038

VO₂AT (mL/kg/min)

20.5 ± 4.1

15.7 ± 3.5^a

16.6 ± 3.8^a

13.6 ± 3.8^a

0.005

VEmax (l/min)

68.2 ± 20.3

60.8 ± 20

49.7 ± 20

56.9 ± 28.9

0.356

HRmax (bpm)

165 ± 14

146 ± 16^a

139 ± 23^a

129 ± 18^a

0.003

HRmax (%)

97.9 ± 34.6

90.0 ± 11.1

82.8 ± 11.5^a

79.3 ± 9.9^a

0.003

SBPmax (mmHg)

197.5 ± 34.6

202.6 ± 25.8

204.2 ± 35.5

201.7 ± 34.3

0.976

DPBmax (mmHg)

89.7 ± 7.5

97.6 ± 9.2

101.8 ± 18.7

98.8 ± 9.6

0.203

6MWT

Distance (m)

627.6 ± 37.8

577.4 ± 66.1

542 ± 57.3^a

531.5 ± 84.2^a

0.012

% Predicted (%)

90.5 ± 7.6

93.9 ± 7.5

83.4 ± 9.5^b

83.0 ± 8.9^b

0.017