Periods | Baseline | Infusion | Post infusion | p (GLM-within) | ||
---|---|---|---|---|---|---|
0-90Â min | 90-150Â min | 150-180Â min | 180-210Â min | 210-240Â min | ||
UO (ml/min) | ||||||
0.9% NaCl | 6.90(1.33) | 8.75(1.76) | 7.95(2.31) | 7.39(2.36) | 8.12(2.26) | <0.0001 |
3% NaCl | 7.12(1.35) | 2.75(0.73) | 1.81(0.64) | 1.98(1.07) | 2.05(1.09)** | |
Glucose | 6.83(1.58) | 11.84(2.28) | 16.05(2.82) | 15.28(2.47) | 13.45(2.47)** | |
p (GLM between) | Â | <0.0001 | Â | Â | Â | Â |
p ANOVA | 0.77 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | Â |
C H2O | ||||||
0.9% NaCl | 3.87(1.55) | 5.29(1.44) | 4.07(2.09) | 3.01(2.04) | 3.62(1.59) | <0.0001 |
3% NaCl | 3.97(1.21) | -0.35(0.73) | -1.87(0.83) | -2.22(0.88) | -2.26(0.96) | |
Glucose | 3.84(1.32) | 6.38(1.77) | 11.60(0.52) | 12.47(2.35) | 11.17(2.12) | |
p (GLM between) | Â | <0.0001 | Â | Â | Â | Â |
p ANOVA | 0.95 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | Â |
U- osm (mosmol/kg) | ||||||
0.9% NaCl | 140(62) | 115(21) | 149(58) | 176(50) | 161(33) | <0.0001 |
3% NaCl | 136(37) | 342(96) | 606(114) | 637(105) | 640(111)* | |
Glucose | 136(41) | 133(21) | 79(21) | 52(12) | 48(7)* | |
p (GLM between) | Â | p <0.0001 | Â | Â | Â | Â |
p ANOVA | 0.95 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | Â |
u-AQP2 (ng/min) | ||||||
0.9% NaCl | 1.03 (0.25) | 1.02(0.22) | 1.22(0.34) | - | 1.26(0.32)* | <0.0001 |
3% NaCl | 1.02(0.22) | 0.99(0.31) | 1.28(0.30) | - | 1.37(0.34)* | |
Glucose | 1.01(0.22) | 1.26(0.25) | 1.19(0.29) | - | 0.78(0.18)* | |
p (GLM between) | Â | 0.274 | Â | Â | Â | Â |
u-AQP2 CR (ng/mmol) | ||||||
0.9% NaCl | 102.5(19.9) | 110.8(18.1) | 119.8(25.4) | - | 125.0(21.0)** | <0.0001 |
3% NaCl | 105.9(15.7) | 108.6(27.2) | 125.1(31.4) | - | 132.7(26.5)* | |
Glucose | 105.7(19.1) | 137.1(22.3) | 118.1(26.5) | - | 87.9(15.4)* | |
p (GLM between) | Â | 0.565 | Â | Â | Â | Â |