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Table 3 Effect of 0.9% isotonic saline (0.9% NaCl), 3% hypertonic saline (3% NaCl) and isotonic glucose (Glucose) on urinary sodium excretion (u-Na), fractional excretion of sodium (FE Na ), urinary potassium wxcretion (u-K), fractional excretion of potassium (FE K ), urinary gamma fraction of the epithelial sodium channels excretion rate (u-ENaCγ) and urinary gamma fraction of ENaC corrected for creatinine (u-ENaCγ CR )

From: Effect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidney

Periods

Baseline

Infusion

Post infusion

p (GLM within)

0-90 min

90-150 min

150-180 min

180-210 min

210-240 min

u-Na (mmol/min)

0.9% NaCl

1.24(0.55)

1.83(0.56)

2.51(1.05)

2.78(0.99)

3.07(0.98)*

<0.0001

3% NaCl

1.38(0.58)

1.86(0.75)

2.65(1.06)

2.94(1.44)

3.17(1.38)*

Glucose

1.23(0.51)

1.38(7.3)

0.94(0.43)

0.83(0.35)

0.72(0.35)*

p (GLM between)

 

<0.0001

    

p (ANOVA)

0.599

0.028

<0.0001

<0.0001

<0.001

 

FE Na

0.9% NaCl

1.26(0.53)

1.93(0.61)

2.35(0.72)

2.67(0.76)

2.80(0.75)*

<0.0001

3% NaCl

1.44(0.61)

2.08(0.81)

2.66(1.07)

3.07(1.27)

3.01(1.26)*

Glucose

1.27(0.53)

1.36(0.64)

0.88(0.37)

0.81(0.37)

0.74(0.37)*

p (GLM between)

 

<0.0001

    

p (ANOVA)

0.465

0.002

<0.0001

<0.0001

<0.0001

 

U-K (mmol/min)

0.9% NaCl

26.5(9.1)

22.5(7.6)

21.1(8.9)

22.7(12.2)

23.5(10.2)***

<0.0001

3% NaCl

25.4(9.2)

17.3(7.3)

16.9(8.1)

20.1(10.5)

21.1(9.9)***

Glucose

24.9(8.7)

17.2(5.8)

10.8(3.7)

9.6(3.2)

11.23(4.4)*

p (GLM between)

 

<0.0001

    

p (ANOVA)

0.827

0.016

<0.0001

<0.0001

<0.0001

 

FE K

0.9% NaCl

28.2(9.9)

23.3(7.4)

20.4(7.8)

21.5(8.2)

21.5(7.9)***

<0.0001

3% NaCl

26.3(9.0)

18.5(6.8)

17.0(7.5)

20.9(9.3)

20.0(8.9)***

Glucose

25.7(8.8)

16.7(5.5)

9.8(3.1)

9.3(3.4)

11.5(4.4)*

p (GLM between)

 

< 0.0001

    

p (ANOVA)

0.624

<0.01

<0.0001

<0.0001

<0.0001

 

u-ENaCγ (ng/min)

0.9% NaCl

351.2(155.0)

302.3(108.5)

341.2(123.0)

-

327.2(111.3)

<0.0001

3% NaCl

358.8(160.0)

375.9(173.7)

462.6(203.4)

-

435.9(168.7)**

Glucose

338.3(150.0)

301.7(128.8)

335.2(185.1)

-

283.7(164.4)***

p (GLM between)

 

0.076

    

u-ENaCγ CR (ng/mmol)

0.9% NaCl

36.25(3.63)

32.98(3.50)

34.40(3.63)

-

32.56(3.57)

<0.001

3% NaCl

37.56(3.70)

43.29(3.58)

45.83(3.72)

-

44.46(3.65)***

Glucose

35.33(3.62)

32.78(3.50)

31.68(3.63)

-

31.71(3.57)

p (GLM between)

 

0.091

    
  1. Values are means with SD in brackets. General linear model (GLM) with repeated measures was performed for comparison within the group and intervention as between subjects factor. One way ANOVA was used for comparison of means between subjects when differences were found. Paired t-test was used for comparison within treatment group at baseline and third post infusion period *p < 0.0001, **p <0.001, *** p < 0.01.
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BMC Nephrology

ISSN: 1471-2369

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