Periods | Baseline | Infusion | Post infusion | p (GLM within) | ||
---|---|---|---|---|---|---|
0-90Â min | 90-150Â min | 150-180Â min | 180-210Â min | 210-240Â min | ||
u-Na (mmol/min) | ||||||
0.9% NaCl | 1.24(0.55) | 1.83(0.56) | 2.51(1.05) | 2.78(0.99) | 3.07(0.98)* | <0.0001 |
3% NaCl | 1.38(0.58) | 1.86(0.75) | 2.65(1.06) | 2.94(1.44) | 3.17(1.38)* | |
Glucose | 1.23(0.51) | 1.38(7.3) | 0.94(0.43) | 0.83(0.35) | 0.72(0.35)* | |
p (GLM between) | Â | <0.0001 | Â | Â | Â | Â |
p (ANOVA) | 0.599 | 0.028 | <0.0001 | <0.0001 | <0.001 | Â |
FE Na | ||||||
0.9% NaCl | 1.26(0.53) | 1.93(0.61) | 2.35(0.72) | 2.67(0.76) | 2.80(0.75)* | <0.0001 |
3% NaCl | 1.44(0.61) | 2.08(0.81) | 2.66(1.07) | 3.07(1.27) | 3.01(1.26)* | |
Glucose | 1.27(0.53) | 1.36(0.64) | 0.88(0.37) | 0.81(0.37) | 0.74(0.37)* | |
p (GLM between) | Â | <0.0001 | Â | Â | Â | Â |
p (ANOVA) | 0.465 | 0.002 | <0.0001 | <0.0001 | <0.0001 | Â |
U-K (mmol/min) | ||||||
0.9% NaCl | 26.5(9.1) | 22.5(7.6) | 21.1(8.9) | 22.7(12.2) | 23.5(10.2)*** | <0.0001 |
3% NaCl | 25.4(9.2) | 17.3(7.3) | 16.9(8.1) | 20.1(10.5) | 21.1(9.9)*** | |
Glucose | 24.9(8.7) | 17.2(5.8) | 10.8(3.7) | 9.6(3.2) | 11.23(4.4)* | |
p (GLM between) | Â | <0.0001 | Â | Â | Â | Â |
p (ANOVA) | 0.827 | 0.016 | <0.0001 | <0.0001 | <0.0001 | Â |
FE K | ||||||
0.9% NaCl | 28.2(9.9) | 23.3(7.4) | 20.4(7.8) | 21.5(8.2) | 21.5(7.9)*** | <0.0001 |
3% NaCl | 26.3(9.0) | 18.5(6.8) | 17.0(7.5) | 20.9(9.3) | 20.0(8.9)*** | |
Glucose | 25.7(8.8) | 16.7(5.5) | 9.8(3.1) | 9.3(3.4) | 11.5(4.4)* | |
p (GLM between) |  | < 0.0001 |  |  |  |  |
p (ANOVA) | 0.624 | <0.01 | <0.0001 | <0.0001 | <0.0001 | Â |
u-ENaCγ (ng/min) | ||||||
0.9% NaCl | 351.2(155.0) | 302.3(108.5) | 341.2(123.0) | - | 327.2(111.3) | <0.0001 |
3% NaCl | 358.8(160.0) | 375.9(173.7) | 462.6(203.4) | - | 435.9(168.7)** | |
Glucose | 338.3(150.0) | 301.7(128.8) | 335.2(185.1) | - | 283.7(164.4)*** | |
p (GLM between) | Â | 0.076 | Â | Â | Â | Â |
u-ENaCγ CR (ng/mmol) | ||||||
0.9% NaCl | 36.25(3.63) | 32.98(3.50) | 34.40(3.63) | - | 32.56(3.57) | <0.001 |
3% NaCl | 37.56(3.70) | 43.29(3.58) | 45.83(3.72) | - | 44.46(3.65)*** | |
Glucose | 35.33(3.62) | 32.78(3.50) | 31.68(3.63) | - | 31.71(3.57) | |
p (GLM between) | Â | 0.091 | Â | Â | Â | Â |