Impact of citrate dialysis fluid on acid–base status. A) Intra-dialytic change in pH at study start (Week 0) and study end (Week 6). B) Intra-dialytic change in Base Excess at study start (Week 0) and study end (Week 6). C) Overall intra-dialytic change in carbon dioxide pressure when using citrate dialysis fluid compared to control. Black bars represent pre-dialysis values and white bars post-dialysis values. Bars show means and error bars represent SEM, n = 20. * = p < 0.05 and ** = p < 0.01.