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Table 4 Clinical characteristics of the CKD patients according to quartiles of FGF23 levels

From: Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study

  FGF23-Quartile 1 FGF23-Quartile 2 FGF23-Quartile 3 FGF23-Quartile 4  
  (n = 47; FGF23, 11–40) (n = 50; FGF23, 41–63) (n = 49; FGF23, 64–103) (n = 49; FG23, 105–2010) p values
Age (years) 67.7 ± 14.2 68.5 ± 10.6 68.2 ± 10.3 70.5 ± 10.0 0.65
Male 26 (55) 33 (66) 35 (71) 35 (71) 0.31
Hypertension 38 (81) 37 (74) 48 (98) 48 (98) <0.01
Diabetes mellitus 20 (43) 20 (40) 29 (59) 23 (47) 0.23
Smoking 23 (49) 29 (58) 30 (61) 28 (57) 0.66
Dyslipidemia 35 (74) 33 (66) 35 (71) 43 (88) 0.06
Body mass index (kg/m2) 22.2 ± 2.5 22.4 ± 5.7 22.7 ± 5.4 22.7 ± 3.5 0.95
Proteinuria (g/day) 1.2 (0.1-3.3) 0.7 (0.1-2.6) 2.2 (0.4-4.0) 1.2 (0.4-3.6) 0.14
C-reactive protein (mg/dL) 0.05 (0.02-0.12) 0.09 (0.03-0.22) 0.13 (0.05-0.26) 0.09 (0.05-0.35)* 0.01
Hemoglobin (g/dL) 11.5 ± 2.2 11.1 ± 2.1 10.6 ± 2.0 9.6 ± 1.7** <0.01
Serum corrected calcium (mg/dL) 9.5 ± 0.6 9.4 ± 0.5 9.5 ± 0.5 9.3 ± 0.6 0.19
Serum phosphorus (mg/dL) 3.4 ± 0.5 3.5 ± 0.6 3.6 ± 0.5 4.4 ± 0.9** <0.01
Ca-P product (mg2/dL2) 32.5 ± 5.6 33.3 ± 6.0 34.4 ± 4.2 40.7 ± 8.5** <0.01
eGFR (ml/min/1.73m2) 46.9 (27.0-68.9) 33.6 (17.3-57.9) 22.0 (16.0-35.0)** 12.7 (9.0-17.2)** <0.01
CAAC 23 (49) 29 (58) 37 (76) 39 (80) <0.01
  1. Values are expressed as the means ± SD, number (percent), or median (interquartile range).
  2. CKD chronic kidney disease, FGF fibroblast growth factor, Ca-P calcium-phosphorus, eGFR estimated glomerular filtration rate, CAAC carotid artery calcification.
  3. *p < 0.05, **p < 0.01 vs. FGF23-Quartile 1.