Table 2 Changes in gastrointestinal symptoms, Bristol stool scale, and metabolic acidosis in patients switched from sevelamer hydrochloride to bixalomer and in control patients
Switch group, n = 24 | Ctrl group, n = 84 | Swich vs.Ctrl | Swich vs.Ctrl | |||||
|---|---|---|---|---|---|---|---|---|
Before | 3 months | P value* | Before | 3 months | P value* | P value** (Before) | P value** (3 months) | |
[Questionnaires] | ||||||||
Reflux | 2.0 ± 2.9 | 1.3 ± 2.4 | 0.044 | 1.3 ± 2.5 | 0.9 ± 1.8 | 0.117 | 0.067 | 0.193 |
Stomach ache | 1.1 ± 1.6 | 1.1 ± 2.0 | 1.000 | 0.8 ± 2.0 | 0.6 ± 2.0 | 0.422 | 0.057 | 0.122 |
Epigastric fullness | 3.0 ± 3.2 | 1.9 ± 3.2 | 0.069 | 1.5 ± 2.1 | 1.3 ± 2.4 | 0.417 | 0.028 | 0.554 |
Constipation | 3.0 ± 2.9 | 1.5 ± 2.0 | 0.004 | 2.1 ± 2.4 | 1.5 ± 2.0 | 0.073 | 0.143 | 0.855 |
Diarrhea | 2.2 ± 2.4 | 1.7 ± 2.1 | 0.274 | 2.1 ± 2.3 | 1.4 ± 2.2 | 0.042 | 0.685 | 0.414 |
Total score | 11.3 ± 10.5 | 7.5 ± 10.1 | 0.011 | 7.9 ± 9.4 | 5.7 ± 8.2 | 0.117 | 0.062 | 0.814 |
Bristol scale | 4.1 ± 1.0 | 4.0 ± 1.0 | 0.704 | 4.4 ± 1.1 | 4.1 ± 1.1 | 0.083 | 0.209 | 0.594 |
[Blood gas analysis] | ||||||||
pH | 7.36 ± 0.04 | 7.39 ± 0.04 | 0.004 | |||||
HCO3- | 19.7 ± 2.3 | 21.3 ± 3.2 | 0.028 | |||||
BE (vt) | −5.0 ± 2.5 | −3.3 ± 3.1 | 0.012 | |||||
Anion Gap | 19.6 ± 3.3 | 15.8 ± 3.1 | 0.000 | |||||