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Table 1 Effects of Imatinib on markers of renal function 20 weeks after induction of chronic anti-thy1 glomerulosclerosis (cGS)

From: Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat

Group/parameter

Creatinine (mg/dL)

Urea (mg/dL)

GFR/100 g body weight mL/min

2-K Control

0.41 ± 0.12

42 ± 10

0.68 ± 0.04

1-K Control

0.49 ± 0.04

44 ± 6

0.49 ± 0.08

cGS

2.43 ± 2.12**

232 ± 182**

0.24 ± 0.16**

cGS + Imatinib

1.42 ± 1.13

148 ± 109

0.32 ± 0.16

  1. Administration of Imatinib was started 7 days after injection of anti-thy1 antibody into uni-nephrectomized rats (cGS + Imatinib). Nonnephritic animals with (1-K Control) and without uninephrectomy (2-K Control) received an injection with similar volumes of PBS. GFR is glomerular filtration rate. Plasma creatinine and urea levels and creatinine clearance served as markers of excretory kidney function. (**p < 0.01 vs Controls).
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BMC Nephrology

ISSN: 1471-2369

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