Ischemia time related pathway analysis of universal interspecies IRI genes. Genes that were significantly affected by IRI in more than one species at each selected time-point were analyzed by Ingenuity pathway tool. The top three significant pathways from each time-point were identified, and those that were present among top pathways at least twice were plotted against time-course of the IRI. The y axis represents negative log of p-value assigned by Ingenuity algorithm (Fisher Exact test) to a pathway. The p-value that corresponds to numeric 0.05 is depicted by the dashed line. The x axis represents time course in log10 format. The position of each depicted pathway in the list of pathways is shown in the insert table.