IRI-induced expression pattern of novel IRI candidate genes CLDNs and TYROBP . Panel A. The expression profiles (Y axis) of CLDN3 and CLDN4 are presented according to the tested time points (X axis). Fold changes (black bars) for each species (labeled on the bottom) are expressed in log10 values. The location of each claudin in the distal nephron is depicted in Panel B (each number corresponds to claudin nomenclature). Panel B . Diagram of nephron. Panel C . The pixilated expression values of TYROBP and CD160 genes in cortex and medulla of kidney is represented by horizontal bars. The error bars are standard deviations among 3 samples.