Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study

Table 2 Univariate correlations between biomarkers and other variables

	AKI	CKD 5	HD	Controls
PlGF	CRP,	EN-RAGE,	–	Age,
	r = 0.57, p = 0.002
	Fibrinogen,
	r = 0.47, p = 0.002	r = 0.34, p = 0.03		r = − 0.41, p = 0.01
	Prealbumin,
	r = − 0.37, p = 0.02
PAPP-A	Albumin	Fibrinogen,	Leucocyte count,	Cholesterol,
	r = − 0.42, p = 0.01	r = − 0.34, p = 0.03	r = − 0.34, p = 0.03
	Transferin,	Serum protein,	Albumin,
	r = 0.36, p = 0.01	r = − 0.38, p = 0.03	r = − 0.038, p = 0.03
	Prealbumin	BUN,	CRP,	r = − 0.44, p = 0.01
	r = − 0.42, p = 0.01	r = 0.32, p = 0.03	r = 0.4, p = 0.02
			Cholesterol,
			r = 0.4, p = 0.02
sRAGE	Haemoglobin,	Leucocyte count,	Ferritin,	EN-RAGE,
	Haemoglobin,	r = − 0.36, p = 0.03	Ferritin,	r = − 0.41, p = 0.01
	r = − 0.44, p = 0.001	GFR,	r = 0.43, p = 0.02	GFR,
	r = − 0.44, p = 0.001	r = − 0.32, p = 0.02	r = 0.43, p = 0.02	r = − 0.37, p = 0.04
EN-RAGE	CRP,	HMGB-1,	HMGB-1,	Prealbumin,
	r = 0.36, p = 0.03		HMGB-1,
	Orosomucoid,		r = 0.63,. p = 0.001
	r = 0.46, p = 0.003		Fibrinogen,
	Ferritin,		r = 0.49, p = 0.01	r = 0.39, p = 0.02
	r = 0.51, p = 0.001	r = 0.38, p = 0.04	CRP,	GFR,
	Leucocyte count,	Age,	r = 0.78, p = 0.001	r = 0.33, p = 0.04
	r = 0.51, p = 0.03	r = − 0.44, p = 0.04	Orosomucoid,	sRAGE,
	GFR,		r = 0.43, p = 0.001	r = − 0.41, p = 0.01
	r = − 0.34, p = 0.04		Leukocyte count,
	BUN,		r = − 0.56, p = 0.01
	r = 0.33, p = 0.03		r = − 0.56, p = 0.01
HMGB-1	Leucocyte count,	Leucocyte count,	CRP,	–
	r = 0.42, p = 0.01		CRP,
	Proteinuria,		r = 0.45, p = 0.01
	r = − 0.36, p = 0.02	r = 0.48, p = 0.001	Total protein,
	Cholesterol,		r = 0.48, p = 0.01
	r = − 0.34, p = 0.03		r = 0.48, p = 0.01

Data are expressed as mean ± SD.
Abbreviations: AKI acute kidney injury, BUN blood urea nitrogen, CKD5 chronic kidney disease stage 5, CRP C-reactive protein, sRAGE soluble receptor for advanced glycation end products, EN-RAGE extracellular newly identified receptor for advanced glycation end products binding protein, HD haemodialysis, HMGB-1 high mobility group box protein-1, PAPP-A pregnancy-associated plasma protein-A, SD standard deviation, GFR glomerular filtration rate.

ISSN: 1471-2369