Figure 1From: Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis Changes in serum Creatinine concentration (umol/L) Over Time; Creatinine levels increase substantially following treatment initiation with varenicline (200–220 umol/L to 319 umol/L). Treatment cessation resulted in little improvement, but prednisone therapy lowered creatinine levels to ~228umol/L. Renal function continued to deteriorate after prednisone therapy was stopped.Back to article page