Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians

BMC Nephrology

Table 4 Sensitivity, specificity and area under the ROC curves at mGFR cut-off values of 60 ml/min/1.73 m ² and 45 ml/min/1.73 m ² for estimating equations

Equation	Sensitivity	Specificity	Area under the curve
Equation	%	%	Area under the curve
MDRD
mGFR < 60 ml/min/1.73 m²	75.0	79.5	0.832 ± 0.042*
mGFR < 45 ml/min/1.73 m²	38.5	82.6	0.763 ± 0.049
CKD-Epi creatinine
mGFR < 60 ml/min/1.73 m²	76.8	79.5	0.836 ± 0.042^†
mGFR < 45 ml/min/1.73 m²	46.2	81.2	0.756 ± 0.050^¶
BIS creatinine
mGFR < 60 ml/min/1.73 m²	96.4	35.9	0.841 ± 0.042
mGFR < 45 ml/min/1.73 m²	65.4	66.7	0.755 ± 0.050^¶
CKD-Epi cystatin C
mGFR < 60 ml/min/1.73 m²	94.6	43.6	0.873 ± 0.035
mGFR < 45 ml/min/1.73 m²	73.1	65.2	0.760 ± 0.057^‡
CKD-Epi creatinine-cystatin C
mGFR < 60 ml/min/1.73 m²	91.1	53.8	0.884 ± 0.034
mGFR < 45 ml/min/1.73 m²	76.9	71.0	0.813 ± 0.049
BIS creatinine-cystatin C
mGFR < 60 ml/min/1.73 m²	98.2	30.8	0.876 ± 0.035
mGFR < 45 ml/min/1.73 m²	76.9	68.1	0.772 ± 0.052^§

Values for the area under the curve are ± SE.
p-values for the comparisons of the area under the curve for the equations at the cut-off value of 60 ml/min/1.73 m²:
*p < 0.06; ^†p = 0.09 compared with CKD-Epi creatinine-cystatin C.
p-values for the comparisons of the area under the curve for the equations at the cut-off value of 45 ml/min/1.73 m²: ^§p = 0.05; ^‡p = 0.06, ^¶p = 0.08 compared with CKD-Epi creatinine-cystatin C.

ISSN: 1471-2369