Figure 6
From: Glomerular tip adhesions predict the progression of IgA nephropathy
Possible mechanism through which glomerular tip adhesions influence the progression of IgA nephropathy. A. Intact glomerulus. B. A glomerular tip adhesion interferes with the flow of original urine, leading to hypofiltration on the side of glomerular tip adhesion and hyperfiltration on the intact side. C. Segmental glomerulosclerosis occurs due to decreased intraglomerular pressure on the side with the glomerular tip adhesion. D. Hyperfiltration in other areas of the glomerulus produces a new glomerular tip adhesion. E. The above changes finally induce global glomerular sclerosis.