Table 2 Data from the multicentric French cohort
From: Thrombocytopenia is not mandatory to diagnose haemolytic and uremic syndrome
All patients | Patients with normal platelets count | Patients with thrombocytopenia | P | |
|---|---|---|---|---|
Number of patients | 107 | 14 | 93 | |
Number of episodes | 145 | 17 | 128 | |
Number of relapsing patients | 18 (20%) | 2 (14%) | 19 (20%) | 0.88 |
Sex (%male) | 29 (27%) | 5 (36%) | 24 (26%) | 0.39 |
Age (years) | 32 [22 – 45] | 32 [22 – 45] | 33 [23 – 42] | 0.78 |
Biopsy proven TMA | 72 (67%) | 13 (93%) | 59 (63%) | |
identification of mutation | 75 (70%) | 10 (71%) | 65 (70%) | 0.95 |
CFH | 40 | 6 | 34 | |
CFI | 17 | 3 | 14 | |
MCP | 10 | 1 | 9 | |
C3 | 11 | 1 | 10 | |
CFB | 2 | |||
Anti-factor H Autoantibody | 2 | |||
Potential explanation | 2 (13.3%) | 1 (14.3%) | 11 (12%) | |
Familial form | 1 | 10 | ||
Low C3 | 2 | 0 | 1 | |
Idiopathic | 21 (23.3%) | 3 (21.4%) | 19 (25%) | |
Pregnancy associated HUS | 19 (18%) | 1 (7%) | 17 (18%) | 0.151 |
Platelets (G/L)* | 79 [48-117] | 214 [186 - 242] | 68 [46-100] | < 0.001 |
Hb (g/dl) | 7.2 [6,6 - 9] | 8.6 [6.7-10] | 7.2 [6.6 - 8.8] | 0.16 |
LDH* (UI/L) | 1688 [951-2930] | 664 [498-1914] | 1711 [999-1953] | 0.017 |
Creatinine (mg/dl) | 7.3 [4.1 - 11.3] | 4.3 [2.6 - 12] | 7.6 [4.6 - 11.3] | 0.27 |
HD at the diagnosis | 13 (12%) | 1 (7%) | 12 (13%) | 0.68 |
HD during the episode | 72 (80%) | 10 (71%) | 62 (81.6%) | 0.6 |
Death Number/% | 6 (6.7%) | 1 (7.1%) | 5 (6.6%) | 0.9 |