Figure 4
From: Intracellular calcium release modulates polycystin-2 trafficking
PC2 trafficking to the PM depends on intracellular Ca 2+ signaling and Ca 2+ -dependent kinases. ( A-B ) Quantitative analysis of PM PC2-positive rPT cells following treatment with 100 μM ouabain with 100 μM 2-APB ( A ), with 10 μM BAPTA ( B ), or with 10 μM KN-93, 10 μM LY294002, 5 μM wortmanin, 20 nM FK506, 1 μM Go6983, 5 μM calphostin, or 100 μM cycloheximide ( C ). Values are the mean ± SEM, ***P < 0.001 vs. control, and #P < 0.001 vs. treatment.