Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study

Table 2 Estimated glomerular filtration rates by alcohol consumption and Mt5178 C/A genotype

Genotype and alcohol consumption	eGFR (ml/min/1.73 m²)	eGFR † (ml/min/1.73 m²)	eGFR ‡ (ml/min/1.73 m²)
Mt5178C (N = 239)
Non-drinkers (N = 44)	75.8 ± 2.0	76.5 ± 1.9	74.5 ± 2.3
Occasional drinkers (N = 84)	81.8 ± 1.4*	81.1 ± 1.3	79.1 ± 1.9
Daily drinkers (N = 111)	78.4 ± 1.2	78.6 ± 1.2	76.8 ± 1.6
	P for trend = 0.667	P for trend = 0.693	P for trend = 0.612
Mt5178A (N = 155)
Non-drinkers (N = 21)	74.3 ± 2.6	75.8 ± 2.6	75.8 ± 3.0
Occasional drinkers (N = 60)	81.3 ± 1.6	81.0 ± 1.5	80.8 ± 2.1
Daily drinkers (N = 74)	83.8 ± 1.4**	83.6 ± 1.4*	83.7 ± 2.0*
	P for trend = 0.003	P for trend = 0.009	P for trend = 0.008

eGFR; estimated glomerular filtration rate. †eGFR is given as least-square mean ± S.E. adjusted for age, body mass index; ‡eGFR is given as least-square mean ± S.E. adjusted for age, body mass index, habitual smoking, coffee consumption and antihypertensive medication use. Bonferroni correction for multiple comparisons was used. *P < 0.05 vs. non-drinkers, **P < 0.01 vs. non-drinkers.

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