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Table 1 Patient characteristics

From: Impact of non-dialysis chronic kidney disease on survival in patients with septic shock

Parameter Overall Non-CKD CKD p value between Non-CKD and CKD
n=163 n=107 n=56
Male gender 93 (57%) 58 (54%) 35 (62%) 0.4
Age (years) 66 (57–76) 63 (54–76) 72 (62–79) <0.001
Diabetes 51 (31%) 20 (19%) 31 (55%) 0.001
HBP 97 (59%) 58 (54%) 39 (70%) 0.08
Heart failure 26 (16%) 7 (6%) 19 (34%) 0.001
Peripheral artery disease 25 (15%) 9 (8%) 16 (28%) 0.002
Coronary artery disease 28 (17%) 11 (10%) 17 (30%) 0.003
COPD 27 (17%) 18 (17%) 9 (16%) 0.9
Statin use 41 (25%) 20 (19%) 21 (37%) 0.01
Admission     
not related to surgery 145 (89%) 97 (91%) 48 (86%) 0.5
related to surgery 18 (11%) 10 (9%) 8 (14%) 0.4
ICU-acquired septic shock 11 (7%) 8 (7%) 3 (5%) 0.8
Baseline eGFR, (ml/min/1.73m2) 67 (44–92) 81 (67–108) 36 (28–44) <0.001
Scr on admission (μmol/l) 241 (137–415) 187 (116–305) 400 (300–520) <0.001
Scr onset of septic shock (μmol/l) 240 (131–390) 203 (102–332) 380 (236–469) <0.001
Hb on admission (g/dl) 10.2 (8.7-12.1) 10.2 (8.6-12.2) 10.2 (8.9-11.8) 0.6
SAPS II 60 (45–78) 58 (43–69) 66 (55–85) 0.005
Days w/o catechol (days) 2 (0–9) 3 (0–9) 0 (0–5) 0.02
Days w/o MV (days) 1 (0–5) 2 (0–5) 1 (0–5) 0.9
Length of stay (days) 7 (3–14) 8 (3–15) 5 (2–13) 0.1
Infection sites     
  lungs 64 (39%) 43 (40%) 21 (37%) 0.9
  abdominal 25 (15%) 16 (15%) 9 (16%) 0.9
  urinary 21 (13%) 12 (11%) 9 (16%) 0.5
  cutaneous 12 (7%) 8 (7%) 4 (7%) 0.8
  endocarditis 2 (1%) 0 2 (3%) -
  bone 2 (1%) 1 (1%) 1 (2%) -
  unknown 35 (21%) 25 (23%) 10 (20%) 0.5
RIFLE Classification 135 (83%) 86 (80%) 49 (87%) 0.4
  Risk 25 (17%) 23 (21%) 2 (3%) <0.001
  Injury 26 (19%) 16 (15%) 10 (18%) 0.3
  Failure 78 (58%) 47 (44%) 31 (63%) 0.08
  Loss of function 6 (4%) 0 6 (12%) -
  ESKD 0 0 0 -
Renal support 75 (46%) 45 (42%) 30 (53%) 0.3
  IHD 46 (33%) 29 (64%) 17 (57%) 0.9
  CVVHDF 32 (23%) 19 (42%) 13 (43%) 0.6
  CVVHF 16 (11%) 12 (27%) 4 (13%) 0.5
28-day mortality 93 (57%) 54 (50%) 39 (70%) 0.03
1-year mortality 115 (71%) 69 (64%) 46 (82%) 0.03
  1. Reported as No. (%) or median (IQR).
  2. CKD chronic kidney disease (Baseline eGFR <60ml/min/1.73m2), Scr serum creatinine, BMI body mass index, HBP High blood pressure, ICU intensive care unit, SAPS II Simplified Acute Physiologic Score II, eGFR estimated glomerular filtration rate, adm. admission, MV mechanical ventilation, catechol. catecholamines, ESKD end-stage kidney disease, IHD intermittent hemodialysis, CVVHDF continuous venovenous hemodiafiltration, CVVHF continuous venovenous hemofiltration.