Skip to main content

Table 2 Removal fraction of insulin and insulin aspart

From: Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study

Time point Study day A-site V-site* RF**
   (pmol/L) (pmol/L) (%)
0 min NT [insulin] 184 ± 91 57 ± 37 75 (58; 85)
G [insulin] 371 ± 274 119 ± 100 70 (63; 76)
GI [insulin] 253 ± 212 85 ± 91 72 (62; 79)
GI [insulin aspart] 481 ± 227 155 ± 56 67 (56; 75)
120 min NT [insulin] 87 ± 63 40 ± 30 55 (50; 59)
G [insulin] 294 ± 237 146 ± 133 53 (49; 56)
GI [insulin] 194 ± 163 94 ± 89 55 (49; 59)
GI [insulin aspart] 462 ± 181 225 ± 75 50 (45; 56)
240 min NT [insulin] 30 ± 20 17 ± 14 52 (32; 67)
G [insulin] 162 ± 115 90 ± 70 47 (44; 51)
GI [insulin] 74 ± 41 39 ± 22 48 (38; 56)
GI [insulin aspart] 464 ± 159 250 ± 114 48 (39; 55)
  1. Abbreviations: NT, no treatment; G, glucose infusion; GI, glucose-insulin infusion; A-site, arterial site; V-site, venous site of the dialyser; RF, removal fraction.
  2. *P < 0.001 for comparison of insulin and insulin aspart concentrations between the A- and V-site at each time point and study day.
  3. **The RF of insulin did not differ between study days and were similar for insulin and insulin aspart. From 0 to 120 min the RF declined for both insulin (p < 0.001, overall) and insulin aspart (p = 0.006), whereas the changes in the RF from 120 to 240 min did not reach statistical significance. Data are expressed as mean ± SD for insulin concentrations and mean (95% confidence interval) for RF.