|
Time point
|
Study day
|
A-site
|
V-site*
|
RF**
|
|---|
| | |
(pmol/L)
|
(pmol/L)
|
(%)
|
|---|
|
0 min
|
NT [insulin]
|
184 ± 91
|
57 ± 37
|
75 (58; 85)
|
|
G [insulin]
|
371 ± 274
|
119 ± 100
|
70 (63; 76)
|
|
GI [insulin]
|
253 ± 212
|
85 ± 91
|
72 (62; 79)
|
|
GI [insulin aspart]
|
481 ± 227
|
155 ± 56
|
67 (56; 75)
|
|
120 min
|
NT [insulin]
|
87 ± 63
|
40 ± 30
|
55 (50; 59)
|
|
G [insulin]
|
294 ± 237
|
146 ± 133
|
53 (49; 56)
|
|
GI [insulin]
|
194 ± 163
|
94 ± 89
|
55 (49; 59)
|
|
GI [insulin aspart]
|
462 ± 181
|
225 ± 75
|
50 (45; 56)
|
|
240 min
|
NT [insulin]
|
30 ± 20
|
17 ± 14
|
52 (32; 67)
|
|
G [insulin]
|
162 ± 115
|
90 ± 70
|
47 (44; 51)
|
|
GI [insulin]
|
74 ± 41
|
39 ± 22
|
48 (38; 56)
|
|
GI [insulin aspart]
|
464 ± 159
|
250 ± 114
|
48 (39; 55)
|
- Abbreviations: NT, no treatment; G, glucose infusion; GI, glucose-insulin infusion; A-site, arterial site; V-site, venous site of the dialyser; RF, removal fraction.
- *P < 0.001 for comparison of insulin and insulin aspart concentrations between the A- and V-site at each time point and study day.
- **The RF of insulin did not differ between study days and were similar for insulin and insulin aspart. From 0 to 120 min the RF declined for both insulin (p < 0.001, overall) and insulin aspart (p = 0.006), whereas the changes in the RF from 120 to 240 min did not reach statistical significance. Data are expressed as mean ± SD for insulin concentrations and mean (95% confidence interval) for RF.
