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Table 2 Association between blood pressure (BP) categories and eGFR <60 mL/min/1.73 m 2 in Chinese population

From: Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults

BP categories No. at risk(cases) Prevalence of eGFR <60 mL/min/1.73 m2(%) Age, sex-adjusted OR (95% CI) Multivariable model 1* OR (95% CI) Multivariable model 2† OR (95% CI)
JNC-7 BP category‡      
   Normal 492 (7) 1.4 1.00 (referent) 1.00 (referent) -
   Prehypertension 771 (10) 1.3 0.55 (0.20-1.50) 0.49 (0.18-1.35)  
   Stage1 hypertension 1057 (88) 8.3 2.14 (0.95-4.82) 1.67 (0.73-3.81)  
   Stage 2 hypertension 847 (115) 13.6 2.29 (1.01-5.18) 1.69 (0.73-3.90)  
   P trend    0.002 0.005  
Hypertensive status      
   Normotensive 1263 (17) 1.4 1.00 (referent) 1.00 (referent) -
   Hypertensive 1904 (203) 10.7 3.27 (1.94-5.53) 2.71 (1.59-4.63)  
Systolic BP quartiles      
   Quartile 1 (82–122 mm Hg) 780 (32) 4.1 1.00 (referent) 1.00 (referent) 1.00 (referent)
   Quartile 2 (123–135 mm Hg) 839 (46) 5.5 0.97 (0.59-1.61) 0.91 (0.54-1.52) 0.81 (0.48-1.37)
   Quartile 3 (136–147 mm Hg) 754 (60) 8.0 0.89 (0.55-1.46) 0.82 (0.50-1.35) 0.75 (0.45-1.25)
   Quartile 4 (148–225 mm Hg) 794 (82) 10.3 0.77 (0.48-1.25) 0.68 (0.42-1.11) 0.64 (0.39-1.07)
   P trend    0.2 0.9 0.8
Each 10 units increase in systolic BP    0.96 (0.88-1.04) 0.94 (0.86-1.02) 0.94 (0.86-1.03)
Diastolic BP quartiles      
   Quartile 1 (50–70 mm Hg) 869 (83) 9.6 1.00 (referent) 1.00 (referent) 1.00 (referent)
   Quartile 2 (71–76 mm Hg) 723 (45) 6.2 0.53 (0.35-0.81) 0.55 (0.36-0.84) 0.53 (0.34-0.83)
   Quartile 3 (77–83 mm Hg) 774 (54) 7.0 0.72 (0.48-1.07) 0.70 (0.47-1.04) 0.69 (0.44-1.08)
   Quartile 4 (84–117 mm Hg) 801 (38) 4.7 0.53 (0.34-0.82) 0.53 (0.34-0.83) 0.63 (0.36-1.09)
   P trend    0.01 0.01 0.1
Each 10 units increase in diastolic BP    0.82 (0.69-0.98) 0.81 (0.68-0.97) 0.87 (0.69-1.09)
Pulse pressure quartiles      
   Quartile 1 (21–46 mm Hg) 786 (23) 2.9 1.00 (Referent) 1.00 (Referent) 1.00 (referent)
   Quartile 2 (47–55 mm Hg) 775 (36) 4.7 0.96 (0.54-1.69) 0.90 (0.51-1.61) 0.85 (0.47-1.54)
   Quartile 3 (56–67 mm Hg) 800 (59) 7.4 1.03 (0.60-1.77) 0.91 (0.53-1.58) 0.80 (0.45-1.39)
   Quartile 4 (68–121 mm hg) 806 (102) 12.7 0.92 (0.53-1.58) 0.80 (0.46-1.39) 0.71 (0.40-1.24)
   P trend    0.7 0.4 0.2
Each 10 units increase in pulse pressure    1.00 (0.90-1.10) 0.97 (0.88-1.08) 0.96 (0.87-1.07)
  1. Abbreviations: eGFR, estimated glomerular filtration rate; OR, odds ratio; CI, confidence interval; * Adjusted for age (years), gender, education (primary and below, high school and above), body mass index (kg/m2), smoking (current, former, never), alcohol intake (present, absent), diabetes status (present, absent).
  2. † Adjusted for variables in model 1 + antihypertensive medication use.
  3. ‡ BP classified according to Seventh Report of the Joint National Committee (JNC 7) on Prevention, Detection, Evaluation, and
  4. Treatment of High Blood Pressure criteria (normal, systolic BP <120 mm Hg and diastolic BP <80 mm Hg; prehypertension,
  5. systolic BP 120–139 or diastolic BP 80–89 mm Hg; stage 1 hypertension, systolic BP 140–159 or diastolic BP 90–99 mm Hg;
  6. stage 2 hypertension, systolic BP ≥160 or diastolic BP ≥100 mm Hg).
  7. Hypertension was defined as a self-reported current use of antihypertensive medication or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg.