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Table 2 Association between blood pressure (BP) categories and eGFR <60 mL/min/1.73 m 2 in Chinese population

From: Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults

BP categories

No. at risk(cases)

Prevalence of eGFR <60 mL/min/1.73 m2(%)

Age, sex-adjusted OR (95% CI)

Multivariable model 1* OR (95% CI)

Multivariable model 2† OR (95% CI)

JNC-7 BP category‡

     

   Normal

492 (7)

1.4

1.00 (referent)

1.00 (referent)

-

   Prehypertension

771 (10)

1.3

0.55 (0.20-1.50)

0.49 (0.18-1.35)

 

   Stage1 hypertension

1057 (88)

8.3

2.14 (0.95-4.82)

1.67 (0.73-3.81)

 

   Stage 2 hypertension

847 (115)

13.6

2.29 (1.01-5.18)

1.69 (0.73-3.90)

 

   P trend

  

0.002

0.005

 

Hypertensive status

     

   Normotensive

1263 (17)

1.4

1.00 (referent)

1.00 (referent)

-

   Hypertensive

1904 (203)

10.7

3.27 (1.94-5.53)

2.71 (1.59-4.63)

 

Systolic BP quartiles

     

   Quartile 1 (82–122 mm Hg)

780 (32)

4.1

1.00 (referent)

1.00 (referent)

1.00 (referent)

   Quartile 2 (123–135 mm Hg)

839 (46)

5.5

0.97 (0.59-1.61)

0.91 (0.54-1.52)

0.81 (0.48-1.37)

   Quartile 3 (136–147 mm Hg)

754 (60)

8.0

0.89 (0.55-1.46)

0.82 (0.50-1.35)

0.75 (0.45-1.25)

   Quartile 4 (148–225 mm Hg)

794 (82)

10.3

0.77 (0.48-1.25)

0.68 (0.42-1.11)

0.64 (0.39-1.07)

   P trend

  

0.2

0.9

0.8

Each 10 units increase in systolic BP

  

0.96 (0.88-1.04)

0.94 (0.86-1.02)

0.94 (0.86-1.03)

Diastolic BP quartiles

     

   Quartile 1 (50–70 mm Hg)

869 (83)

9.6

1.00 (referent)

1.00 (referent)

1.00 (referent)

   Quartile 2 (71–76 mm Hg)

723 (45)

6.2

0.53 (0.35-0.81)

0.55 (0.36-0.84)

0.53 (0.34-0.83)

   Quartile 3 (77–83 mm Hg)

774 (54)

7.0

0.72 (0.48-1.07)

0.70 (0.47-1.04)

0.69 (0.44-1.08)

   Quartile 4 (84–117 mm Hg)

801 (38)

4.7

0.53 (0.34-0.82)

0.53 (0.34-0.83)

0.63 (0.36-1.09)

   P trend

  

0.01

0.01

0.1

Each 10 units increase in diastolic BP

  

0.82 (0.69-0.98)

0.81 (0.68-0.97)

0.87 (0.69-1.09)

Pulse pressure quartiles

     

   Quartile 1 (21–46 mm Hg)

786 (23)

2.9

1.00 (Referent)

1.00 (Referent)

1.00 (referent)

   Quartile 2 (47–55 mm Hg)

775 (36)

4.7

0.96 (0.54-1.69)

0.90 (0.51-1.61)

0.85 (0.47-1.54)

   Quartile 3 (56–67 mm Hg)

800 (59)

7.4

1.03 (0.60-1.77)

0.91 (0.53-1.58)

0.80 (0.45-1.39)

   Quartile 4 (68–121 mm hg)

806 (102)

12.7

0.92 (0.53-1.58)

0.80 (0.46-1.39)

0.71 (0.40-1.24)

   P trend

  

0.7

0.4

0.2

Each 10 units increase in pulse pressure

  

1.00 (0.90-1.10)

0.97 (0.88-1.08)

0.96 (0.87-1.07)

  1. Abbreviations: eGFR, estimated glomerular filtration rate; OR, odds ratio; CI, confidence interval; * Adjusted for age (years), gender, education (primary and below, high school and above), body mass index (kg/m2), smoking (current, former, never), alcohol intake (present, absent), diabetes status (present, absent).
  2. † Adjusted for variables in model 1 + antihypertensive medication use.
  3. ‡ BP classified according to Seventh Report of the Joint National Committee (JNC 7) on Prevention, Detection, Evaluation, and
  4. Treatment of High Blood Pressure criteria (normal, systolic BP <120 mm Hg and diastolic BP <80 mm Hg; prehypertension,
  5. systolic BP 120–139 or diastolic BP 80–89 mm Hg; stage 1 hypertension, systolic BP 140–159 or diastolic BP 90–99 mm Hg;
  6. stage 2 hypertension, systolic BP ≥160 or diastolic BP ≥100 mm Hg).
  7. Hypertension was defined as a self-reported current use of antihypertensive medication or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg.
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BMC Nephrology

ISSN: 1471-2369

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