The natural history of, and risk factors for, progressive Chronic Kidney Disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol

Table 3 The hypotheses that the RIISC cohort aims to address

Risk factor for CKD progression	There are unidentified novel risk factors for CKD progression
	Novel risk factors are a component of the enhanced cardiovascular risk experienced by individuals with CKD
	The presence of periodontitis contributes to both progressive CKD and CVD risk by a mechanism of increasing the systemic inflammatory burden
The phenotype of progressive CKD	The vascular, renal, oral and systemic inflammatory phenotypes of patients with progressive CKD are inter-related.
The phenotype of progressive CKD	The establishment of a cohort of high risk CKD patients with detailed vascular, renal, oral and systemic inflammatory phenotyping at various time-points over a ten year period will provide data on the changing patho-biology of progressive CKD.

ISSN: 1471-2369