Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects

Table 5 Effect of tolvaptan at baseline and during inhibition of the nitric oxide system on brachial systolic- and diastolic blood pressure (SBP and DBP), and pulse rate in a randomized, placebo-controlled, double-blind, crossover study of 19 healthy subjects

Periods	Baseline	L-NMMA		Post infusion		p (GLM-within)
	0-90 min	90-120 min	120-150 min	150-180 min	180-210 min	p (GLM-within)
SBP (mmHG)
Placebo	112 ± 8	113 ± 9	115 ± 8^*	115 ± 9^*	116 ± 10^*	0.170
Tolvaptan	112 ± 11	115 ± 9^*	116 ± 9^*	116 ± 10^*	114 ± 9	0.170
p (GLM between) 0.876
p (paired t-test, between)	0.833	0.117	0.272	0.929	0.430
DBP (mmHg)
Placebo	61 ± 5	68 ± 6^***	67 ± 6^***	67 ± 5^*	65 ± 7	0.688
Tolvaptan	63 ± 5	69 ± 7^***	68 ± 6^***	67 ± 6	66 ± 7	0.688
p(GLM between) 0.606
p (paired t-test, between)	0.049	0.467	0.259	0.907	0.454
Pulse rate (BPM)
Placebo	57 ± 10	52 ± 9^***	53 ± 9^***	55. ± 11^***	58 ± 12^***	0.889
Tolvaptan	55 ± 10	50 ± 9^***	51 ± 9^***	53 ± 10^***	56 ± 11^*	0.889
p (GLM between) 0.527
p (paired t-test, between)	0.016	0.022	0.007	0.013	0.003

Data are shown as mean with ± SD or medians with ± interquartile range. General linear model (GLM) with repeated measures was performed for comparison within the group and intervention as between subjects factor. Post-hoc Bonferoni test (*) was used for comparison of infusion period 90–150 min vs baseline and post infusion period 150–210 vs baseline. Paired t-test or Wilcoxon signed rank test was used for comparison between treatment group at baseline vs during infusion period 90–150 min, and at baseline vs post infusion period 150–210 min. ^*p < 0.05; ^**p < 0.001;^*** p < 0.0001.

ISSN: 1471-2369