Table 2 Clinical characteristics of the 67 cases of AKI based on final adjudication
From: Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study
Pre-renal azotemia (n = 13) | Acute tubular necrosis (n = 41) | Indeterminate (n = 13) | p-value* | |
|---|---|---|---|---|
Pre-op Factors | ||||
Age (years) | 72.9 (11.6) | 72.5 (9.4) | 75.7 (8.4) | 0.68 |
Female sex | 6 (46%) | 16 (39%) | 5 (39%) | 0.65 |
BMI | 30.5 (5.6) | 32.3 (7.2) | 29.1 (6.8) | 0.51 |
Caucasian Race | 13 (100%) | 38 (93%) | 11 (85%) | 0.32 |
Diabetes Mellitus | 9 (69%) | 20 (49%) | 4 (31%) | 0.20 |
Baseline Serum Creatinine (mg/dL) | 1.01 (0.31) | 1.14 (0.38) | 1.06 (0.34) | 0.39 |
Baseline eGFR (CKD-EPI) ml/min | 68.99 (18.77) | 63.28 (21.95) | 67.68 (21.33) | 0.37 |
Repeat Cardiac Surgery | 2 (17%) | 9 (22%) | 3 (23%) | 0.69 |
Pre-op Contrast Exposure | 3 (23%) | 2 (4.9%) | 1 (7.7%) | 0.05 |
Intra-op Factors | ||||
Type of Surgery | 0.95 | |||
CABG alone | 5 (39%) | 15 (37%) | 9 (75%) | |
Valve alone | 3 (23%) | 11 (27%) | 3 (25%) | |
CABG and Valve | 5 (39%) | 15 (37%) | 0 (0%) | |
Off-Pump Surgery | 0 (0%) | 2 (5%) | 3 (23%) | 0.44 |
CPB Time (min) | 103.54 (44.34) | 139.03 (62.11) | 117.44 (59.54) | 0.07 |
Cross Clamp Time (min) | 84 (40.66) | 95.21 (44.08) | 81.89 (47.01) | 0.45 |
Post op Factors | ||||
Length of ICU stay (days) | 2.38 (1.45) | 12.02 (30.74) | 4.38 (4.44) | 0.29 |
Length of Hospitalization (days) | 6.77 (1.92) | 17.49 (32.23) | 7.85 (3.65) | 0.07 |
Received RRT | 0 (0%) | 6 (15%) | 0 (0%) | 0.14 |
Maximum Serum Post op Creatinine (mg/dl) | 1.64 (0.55) | 2.18 (0.76) | 1.84 (0.58) | 0.03 |
Absolute Increase of Maximum Serum Creatinine (mg/dL) | 0.63 (0.25) | 1.04 (0.55) | 0.77 (0.39) | 0.01 |
Maximum% Increase of Serum Creatinine (%) | 62 (12) | 96 (59) | 76 (48) | 0.03 |
Duration of AKI (Days) | 1 [1, 2] | 2 [1, 4] | 1 [0.5, 1] | 0.0002 |
Urine Output/Fluid Balance | ||||
Urine output 0-6 hr (mls) | 1435 [1185, 2643] | 1085 [890, 1395] | 1015 [667, 1600] | 0.04 |
Urine output day 2 (mls) | 1916 [1151, 3200] | 1030 [710, 1505] | 2095 [925, 3075] | 0.02 |
Urine output day 3 (mls) | 2000 [1620, 3690] | 1315 [800, 1760] | 1133 [733, 1950] | 0.01 |
Net fluid Balance 0-6 hr | 1716 [665, 1961] | 1488 [437, 2504] | 1251 [783, 1836] | 0.65 |
Net fluid Balance Day 2 | 539 [-1920, 1839] | 2040 [68, 3438] | 79 [-835, 2110] | 0.16 |
Net fluid Balance Day 3 | 510 [-1493, 790] | 225 [-386, 1532] | -122 [-572, 1054] | 0.43 |
RIFLE “I” n (%) | 0 (0%) | 16 (39%) | 3 (23%) | 0.01 |
RIFLE “F” n (%) | 0 (0%) | 4 (9.8%) | 1 (7.7%) | 0.24 |
Hospital Mortality n (%) | 0 (0%) | 6 (15%) | 1 (7.7%) | 0.16 |