Figure 1

Scr before (shaded square symbol) and 24 h after ( □ ) ischemia–reperfusion injury. Ischemia–reperfusion injury and treatment with saline vehicle resulted in significant elevation of the Scr level after 24 h. Treatment with ATO after ischemia–reperfusion injury (IR + ATO) reduced the impairment of kidney function compared with the IR group (one-way ANOVA test; p < 0.05; n = 8). A right nephrectomy without ischemia of the contralateral kidney (sham) did not increase the Scr level after 24 h.