Figure 3

Morphological damage in the renal cortex of proximal tubules. Ischemia–reperfusion caused severe damage, with loss of the brush border, tubular dilatation, detachment of epithelial cells from the basement membrane, and necrosis of tubular casts. (B) ATO treatment (IR + ATO) markedly reduced the pathological changes noted above. (C) Control animals after right nephrectomy without ischemia (sham) exhibited almost no abnormalities in the contralateral kidney. (A) H&E. Magnification, ×40 in A–C.