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Table 3 R2* values in the control group and in the type 2 diabetic nephropathy groups injected with iodinated contrast agents

From: Effects of iodinated contrast agents on renal oxygenation level determined by blood oxygenation level dependent magnetic resonance imaging in rabbit models of type 1 and type 2 diabetic nephropathy

Kidney tissue

Treatment

1 h

24 h

48 h

72 h

Cortex

CG

19.0 ± 2.3

18.9 ± 2.1

19.2 ± 2.2

18.9 ± 2.7

 

DN PC

24.5 ± 3.6*

24.5 ± 4.3*

24.7 ± 4.5*

25.4 ± 3.7*

 

DN 200

31.1 ± 3.2*

31.3 ± 4.9*

30.9 ± 3.6*

28.9 ± 4.3*

 

DN 240

33.3 ± 4.6*

34.8 ± 4.8*

34.0 ± 3.1*

33.5 ± 7.9*

 

DN 300

41.7 ± 5.1*

41.9 ± 3.4*

40.1 ± 5.5*

39.2 ± 4.0*

 

DN 350

46.7 ± 5.2*

50.2 ± 5.8*

48.9 ± 5.7*

43.7 ± 6.0*

 

DN 400

50.1 ± 5.6*

57.6 ± 5.3*

53.9 ± 6.1*

47.4 ± 5.5*

Outer medulla

CG

20 ± 4.2

22.7 ± 4.8

22.4 ± 5.4

21.6 ± 5.1

 

DN PC

29.9 ± 4.4*

30.7 ± 5.1*

28.2 ± 5.8*

29.5 ± 5.4*

 

DN 200

38.1 ± 4.6*

40.1 ± 6.2*

37.5 ± 4.8*

33.8 ± 5.8*

 

DN 240

42.3 ± 3.5*

43.3 ± 5.7*

40.3 ± 4.2*

37.3 ± 3.5*

 

DN 300

53.4 ± 5.2*

57.9 ± 5.6*

48.8 ± 4.8*

45.4 ± 5.2*

 

DN 350

60.6 ± 6.3*

72.4 ± 5.7*

62.9 ± 5.5*

56.5 ± 5.3*

 

DN 400

67.6 ± 5.6*

80.4 ± 6.3*

74.7 ± 6.1*

67.7 ± 5.8*

Inner medulla

CG

20.2 ± 2.4

20.0 ± 3.6

21.8 ± 2.7

20.5 ± 3.2

 

DN PC

22.7 ± 4.7*

24.5 ± 3.8*

24.3 ± 4.0*

22.9 ± 3.4*

 

DN 200

27.2 ± 3.3*

30.6 ± 4.0*

26.2 ± 2.7*

25.0 ± 3.5*

 

DN 240

30.4 ± 3.8*

33.6 ± 5.8*

31.9 ± 4.2*

29.9 ± 5.2*

 

DN 300

42.8 ± 5.2*

44.2 ± 5.0*

38.8 ± 4.9*

32.7 ± 4.8*

 

DN 350

49.2 ± 5.7*

50.2 ± 4.8*

47.3 ± 5.8*

39.4 ± 5.1*

 

DN 400

55.2 ± 5.4*

57.2 ± 5.3*

55.3 ± 6.3*

46.4 ± 5.7*

  1. Abbreviations: CG control group, DN diabetic nephropathy, PC positive control; 200 200 mg I/mL contrast agent; 240 240 mg I/mL contrast agent, 300 300 mgI/mL contrast agent, 350 350 mg I/mL contrast agent, 400 400 mg I/mL contrast agent.
  2. The control group and the DN PC group were injected with physiological saline/.
  3. Values are means ± standard deviation.
  4. *P < 0.05 vs. the control group.