Table 8 Concordance correlation coefficients (and 95% confidence intervals) for 3 processes using 5 methods based on Cystatin C assay
From: Assessing the agreement of biomarker data in the presence of left-censoring
Processes | Method 1 | Method 2 | Method 3 | Method 4 | Method 5 |
|---|---|---|---|---|---|
Delete the pair | Replace by LOD | Replace by 0.5 × LOD | Replace by c× LOD | ML | |
A (Initial 48 hours: 4°C vs- 80°C) | 0.9348 (0.89, 0.98) | 0.9641 (0.94, 0.98) | 0.9641 (0.94, 0.98) | 0.9641 (0.94, 0.98) | 0.9735 (0.95, 0.99) |
B (Initial 48 hours: 25°C vs −80°C) | 0.9320 (0.89, 0.98) | 0.9514 (0.92, 0.98) | 0.9514 (0.92, 0.98) | 0.9514 (0.92, 0.98) | 0.9471 (0.91, 0.98) |
C (Centrifuge vs No Centrifuge) | 0.9985 (0.99, 1.00) | 0.9982 (0.99, 1.00) | 0.9758 (0.96, 0.99) | 0.9653 (0.95, 0.98) | 0.9999 (0.99, 1.00) |