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Figure 1 | BMC Nephrology

Figure 1

From: Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients

Figure 1

Concentration of complement product C5a measured at inlet (C i ), outlet (C o ), in the ultrafiltrate (C uf ) and total mass production rate (M tp ) over time (median and interquartile range). Results of generalized estimating equations (symbols: no anticoagulation ■ heparin ▲ citrate) for C5a in A. Ci: highest in the citrate group (P = 0.016). B. Co: highest in the citrate group (P = 0.026), decreases over time (P = 0.012) but least in the citrate group (P = 0.008). C. Cuf: lowest in the citrate group (P < 0.001), decreases over time (P < 0.001). D. Mtp: decreases over time (P < 0.001), most in the heparin group (P = 0.007 for interaction).

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