Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis

BMC Nephrology

Table 2 Comparison of small solute transport, water transport pathways and effluent markers between patients with and without ultrafiltration failure

	Patients with UFF Mean ± SD Median (IQR 25-75%)	Patients without UFF Mean ± SD Median (IQR 25-75%)
Patients (n)	9	59
Time on PD (months)	6.0 (4.0 – 35.5)	7.0 (4.0 – 27.0)
Total UF at 4 hour (mL)	305.56 ± 113.04^a	724.58 ± 184.38^a
SPUF (mL)	192.89 ± 59.41^a	343.27 ± 125.68^a
FWT (mL)	134.89 ± 35.07^b	190.64 ± 63.25^b
FWT_corrected(mL)	165.22 ± 31.93^c	233.10 ± 65.95^c
%FWT	41.87 ± 13.07	36.43 ± 11. 53
%FWT_corrected	51.16 ± 12.29	44.59 ± 10.77
D/P _Creatinine	0.81 ± 0.12	0.75 ± 0.11
MTAC _Creatinine (mL/min)	14.88 ± 8.23	10.78 ± 6.87
Effluent HGF (pg/mL)	103.01 (79.83 – 110.78)^d	77.07 (68.05 – 92.58)^d
Effluent VEGF (pg/mL)	15.10 ± 5.68	13.79 ± 4.82
CA125 (U/mL)	24.63 ± 19.63	18.89 ± 9.75
HGF/CA125 (pg/U)	6.22 (2.28 – 8.27)	4.64 (3.30 – 6.36)
VEGF/CA125 (pg/U)	0.70 (0.53 – 1.39)	0.76 (0.54 – 1.08)

SD = standard deviation; UF = ultrafiltration; SPUF = UF through the small pores at 60 minutes; FWT = free water transport at 60 minutes; FWT_corrected = FWT with an algorithm correction according to Venturoli and Rippe [16]; MTAC = mass transfer area coefficient; D/P = dialysate-to-plasma ratio; HGF = hepatocyte growth factor; VEGF = vascular endothelial growth factor; CA 125 = cancer antigen 125.
^aMann–Whitney U test p <0.0001, comparing patients with and without ultrafiltration failure.
^bMann–Whitney U test p = 0.006, comparing patients with and without ultrafiltration failure.
^cMann–Whitney U test p = 0.002, comparing patients with and without ultrafiltration failure.
^dMann–Whitney U test p = 0.018, comparing patients with and without ultrafiltration failure.

ISSN: 1471-2369