Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis

BMC Nephrology

Table 3 FWT profile in patients without UFF: comparison of small solute transport, water transport pathways and effluent markers between patients with FWT ≤ 45% and FWT > 45%

	Patients without ultrafiltration failure
	Patients with FWT ≤ 45% Mean ± SD Median (IQR 25-75%)	Patients with FWT > 45% Mean ± SD Median (IQR 25-75%)
Patients (n)	33	26
Time on PD (months)	6.0 (4.0 – 19.0)	8.5 (5.0 – 30.25)
Total UF at 4 hour (mL)	739.39 ± 210.56	705.77 ± 146.51
SPUF (mL)	412.9 ± 108.54^a	254.81 ± 83.74^a
FWT (mL)	173.42 ± 60.43^b	212.50 ± 60.98^b
FWT_corrected(mL)	221.51 ± 66.11	247.81 ± 63.97
%FWT	29.10 ± 6.50^a	45.74 ± 9. 66^a
%FWT_corrected	37.56 ± 5.62^a	53.52 ± 8.96^a
D/P _Creatinine	0.76 ± 0.08	0.73 ± 0.14
MTAC _Creatinine (mL/min)	10.45 ± 5.14	11.20 ± 8.69
Effluent HGF (pg/mL)	77.17 (68.42 – 93.89)	75.89 (66.47 – 86.51)
Effluent VEGF (pg/mL)	14.19 ± 4.96	13.28 ± 4.68
CA125 (U/mL)	22.28 ± 10.90^c	14.56 ± 5.82^c
HGF/CA125 (pg/U)	3.65 (2.96 – 5.60) ^d	5.19 (4.02 – 8.37) ^d
VEGF/CA125 (pg/U)	0.68 (0.51 – 0.90)	0.89 (0.67 – 1.29)

Variables presented as mean ± SD or median (interquartile range) accordingly. SD = standard deviation; UF = ultrafiltration; SPUF = UF through the small pores at 60 minutes; FWT = free water transport at 60 minutes; FWT_corrected = FWT with an algorithm correction according to Venturoli and Rippe [16]; MTAC = mass transfer area coefficient; D/P = dialysate-to-plasma ratio; HGF = hepatocyte growth factor; VEGF = vascular endothelial growth factor; CA 125 = cancer antigen 125.
a) T-test p <0.0001, comparing patients with FWT ≤ 45% and FWT > 45%.
b) T-test p = 0.017, comparing patients with FWT ≤ 45% and FWT > 45%.
c) T-test p = 0.001, comparing patients with FWT ≤ 45% and FWT > 45%.
d) Mann–Whitney U test p = 0.014, comparing patients with FWT ≤ 45% and FWT > 45%.

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