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Table 6 This table shows logistic regression analysis at 30 days with AKI defined by absolute change as separate groups

From: Do acute elevations of serum creatinine in primary care engender an increased mortality risk?

Model

Variable

Odds Ratio (95% CI)

P-value

5

No AKI

1

<0.001

-AKI 1

 18.8 (12.0, 29.7)

 

-AKI 1a

 8.26 (54.4, 12.9)

 

-AKI 2

 88.7 (98.7, 145)

 

-AKI 3

 269 (148, 488)

 

-AKI 3a

 24.4 (3.30, 181)

 

6

No AKI

1

<0.001

-AKI 1

 14.0 (8.84, 22.2)

 

-AKI 1a

 4.42 (2.81, 6.97)

 

-AKI 2

 59.4 (35.7, 98.8)

 

-AKI 3

 233 (121, 447)

 

-AKI 3a

 25.6 (3.33, 197)

 

Female sex

 0.61 (0.44, 0.85)

<0.001

Age(*)

-Linear term

 0.61 (0.22, 1.68)

<0.001

 

-Squared term

 1.09 (1.02, 1.17)

 

7

No AKI

1

<0.001

-AKI 1

 9.69 (5.91, 15.9)

 

-AKI 1a

 3.99 (2.46, 6.49)

 

-AKI 2

 42.9 (24.5, 75.1)

 

-AKI 3

 237 (115, 490)

 

-AKI 3a

 44.5 (4.83, 409)

 

Female sex

 0.62 (0.44, 0.88)

0.007

Age(*)

-Linear term

 0.39 (0.14, 1.10)

<0.001

 

-Squared term

 1.13 (1.06, 1.22)

 

Any malignancy

 3.62 (2.31, 5.67)

<0.001

CHF

 2.32 (1.36, 3.94)

0.002

CPD

 1.07 (0.63, 1.82)

0.81

Cerebrovascular disease

 0.48 (0.23, 0.98)

0.05

Dementia

 4.88 (2.48, 9.60)

<0.001

Diabetes

 1.19 (0.75, 1.89)

0.45

Hemiplegia or paraplegia

 2.87 (0.91, 9.09)

0.07

Hypertension

 1.24 (0.85, 1.80)

0.26

MI

 0.79 (0.39, 1.62)

0.52

Solid tumour

 8.15 (4.53, 14.6)

<0.001

Mild liver disease

 2.48 (0.88, 7.01)

0.09

PVD

 1.18 (0.58, 2.41)

0.64

Peptic ulcer

 2.82 (1.00, 7.93)

0.05

Renal disease

 0.48 (0.24, 0.96)

0.04

Rheumatic disease

 0.63 (0.22, 1.81)

0.39

Missing data

 1.45 (0.82, 2.54)

0.20

GFR > 60

1

0.92

GFR 45 - < 60

 0.95 (0.61, 1.48)

 

GFR 30 - < 45

 0.92 (0.53, 1.58)

 

GFR < 30

 1.24 (0.53, 2.91)

 

Time measurement (†)

 0.84 (0.80, 0.89)

<0.001

8

No AKI

1

<0.001

-AKI 1

 9.55 (5.89, 15.5)

 

-AKI 1a

 3.63 (2.24, 5.87)

 

-AKI 2

 38.9 (22.8, 66.3)

 

-AKI 3

 163 (81.6, 327)

 

-AKI 3a

 27.0 (3.00, 243)

 

Female sex

 0.67 (0.48, 0.94)

0.02

Age (*)

Linear term

 0.54 (0.20, 1.48)

<0.001

 

Squared term

 1.10 (1.03, 1.18)

 

Charlson

≤0

1

<0.001

 

1-10

 2.92 (1.73, 4.93)

 
 

11+

 5.95 (3.68, 9.64)

 
 

No info

 1.97 (1.06, 3.66)

 

GFR > 60

1

0.45

GFR 45 - < 60

 0.80 (0.52, 1.23)

 

GFR 30 - < 45

 0.70 (0.41, 1.18)

 

GFR < 30

 0.69 (0.31, 0.56)

 

Time measurement (†)

 0.84 (0.80, 0.88)

<0.001

  1. (*) Odds Ratio reported for a 10-year increase in age.
  2. (†) Time from baseline to AKI creatinine measurement (months).
  3. This table shows the logistic regression analysis for the like-hood of dying in the first 30 days following an acute elevation in serum creatinine. Model 6 adjusts for age and gender, model 7 also adjusts for individual co-morbidity and time between incident creatinine and baseline creatinine, model 8 replaces co-morbidity with a Charlson score to measure the effect of cumulative co-morbidity burden and time between incident creatinine and baseline creatinine.
  4. Chronic Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), Myocardial Infarction (MI), Peripheral Vascular Disease (PVD), Chronic Kidney Disease (CKD).