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Table 3 Percentage who progressed to incident CKD*, according to different definitions of RP

From: Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

Years of follow-up considered Number of eGFR per year Excluded in analysis RP definition A RP definition B
aRP (PPV) bnon-RP (1-NPV) Sensitivity (%) Specificity (%) RP (PPV) non-RP (1-NPV) Sensitivity (%) Specificity (%)
Declines of >5 ml/min/1.73 m2required to meet the RP definition
Four Three 65/18948 (0.3) 13/108(12.0) 21/3547 (0.6) 38.2 97.4 0/15 (0.0) 34/3640 (0.9) 0.0 99.6
Four Two 42/14305 (0.3) 23/256 (9.0) 34/8042 (0.4) 40.4 97.2 2/43 (4.7) 55/8255 (0.7) 3.5 99.5
Three Three 47/16228 (0.3) 15/195 (7.7) 37/6180 (0.6) 28.8 97.2 4/85 (4.7) 48/6290 (0.8) 7.7 98.7
Three Two 24/10320 (0.2) 20/369 (5.4) 55/11914 (0.5) 26.7 97.1 7/173 (4.1) 68/12110 (0.6) 9.3 98.6
Two Three 28/11847 (0.2) 14/355 (3.9) 57/10401 (0.6) 19.7 96.8 16/476 (3.4) 55/10280 (0.5) 22.5 95.7
Two Two 7/5392 (0.1) 20/602 (3.3) 72/16609 (0.4) 21.7 96.6 23/779 (3.0) 69/16432 (0.4) 25.0 95.6
    Declines of >3 ml/min/1.73 m 2 required to meet the RP definition
Four Three 65/18948 (0.3) 18/218 (8.3) 16/3437 (0.5) 52.9 94.5 3/37 (8.1) 31/3618 (0.9) 8.8 99.1
Four Two 42/14305 (0.3) 27/506 (5.3) 30/7792 (0.4) 47.4 94.2 6/97 (6.2) 51/8201 (0.6) 10.5 98.9
Three Three 47/16228 (0.3) 21/325 (6.5) 31/6050 (0.5) 40.4 95.2 8/151 (0.7) 44/6224 (27.5) 15.4 97.7
Three Two 24/10320 (0.2) 25/602 (4.2) 50/11681 (0.4) 33.3 95.3 14/292 (4.8) 61/11991 (0.5) 18.7 97.7
Two Three 28/11847 (0.2) 20/527 (3.8) 51/10229 (0.5) 28.2 95.3 22/633 (2.8) 49/10123 (0.5) 31.0 94.3
Two Two 7/5392 (0.1) 30/885 (3.4) 62/16326 (0.4) 32.6 95.0 32/1021(4.5) 60/16190 (0.4) 34.8 94.2
  1. *Two consecutive eGFR measurements <60 ml/min/1.73 m2.
  2. aRP: Rapid Progressors who developed CKD (i.e., the positive predictive value (PPV)).
  3. bNon-RP: non-Rapid Progressors who developed CKD (i.e., 1-negative predictive value (NPV)).