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Table 3 Percentage who progressed to incident CKD*, according to different definitions of RP

From: Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

Years of follow-up considered

Number of eGFR per year

Excluded in analysis

RP definition A

RP definition B

aRP (PPV)

bnon-RP (1-NPV)

Sensitivity (%)

Specificity (%)

RP (PPV)

non-RP (1-NPV)

Sensitivity (%)

Specificity (%)

Declines of >5 ml/min/1.73 m2required to meet the RP definition

Four

Three

65/18948 (0.3)

13/108(12.0)

21/3547 (0.6)

38.2

97.4

0/15 (0.0)

34/3640 (0.9)

0.0

99.6

Four

Two

42/14305 (0.3)

23/256 (9.0)

34/8042 (0.4)

40.4

97.2

2/43 (4.7)

55/8255 (0.7)

3.5

99.5

Three

Three

47/16228 (0.3)

15/195 (7.7)

37/6180 (0.6)

28.8

97.2

4/85 (4.7)

48/6290 (0.8)

7.7

98.7

Three

Two

24/10320 (0.2)

20/369 (5.4)

55/11914 (0.5)

26.7

97.1

7/173 (4.1)

68/12110 (0.6)

9.3

98.6

Two

Three

28/11847 (0.2)

14/355 (3.9)

57/10401 (0.6)

19.7

96.8

16/476 (3.4)

55/10280 (0.5)

22.5

95.7

Two

Two

7/5392 (0.1)

20/602 (3.3)

72/16609 (0.4)

21.7

96.6

23/779 (3.0)

69/16432 (0.4)

25.0

95.6

   

Declines of >3 ml/min/1.73 m 2 required to meet the RP definition

Four

Three

65/18948 (0.3)

18/218 (8.3)

16/3437 (0.5)

52.9

94.5

3/37 (8.1)

31/3618 (0.9)

8.8

99.1

Four

Two

42/14305 (0.3)

27/506 (5.3)

30/7792 (0.4)

47.4

94.2

6/97 (6.2)

51/8201 (0.6)

10.5

98.9

Three

Three

47/16228 (0.3)

21/325 (6.5)

31/6050 (0.5)

40.4

95.2

8/151 (0.7)

44/6224 (27.5)

15.4

97.7

Three

Two

24/10320 (0.2)

25/602 (4.2)

50/11681 (0.4)

33.3

95.3

14/292 (4.8)

61/11991 (0.5)

18.7

97.7

Two

Three

28/11847 (0.2)

20/527 (3.8)

51/10229 (0.5)

28.2

95.3

22/633 (2.8)

49/10123 (0.5)

31.0

94.3

Two

Two

7/5392 (0.1)

30/885 (3.4)

62/16326 (0.4)

32.6

95.0

32/1021(4.5)

60/16190 (0.4)

34.8

94.2

  1. *Two consecutive eGFR measurements <60 ml/min/1.73 m2.
  2. aRP: Rapid Progressors who developed CKD (i.e., the positive predictive value (PPV)).
  3. bNon-RP: non-Rapid Progressors who developed CKD (i.e., 1-negative predictive value (NPV)).