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Table 2 Comparison of subjects with chronic kidney disease (CKD) estimated by the Cockcroft-Gault, abbreviated MDRD and CKD-EPI equations

From: Medication safety and chronic kidney disease in older adults prescribed metformin: a cross-sectional analysis

 

Cockcroft-Gault

Abbreviated MDRD

CKD-EPI

P-value

Frequency CKD stage 3 or higher, N (%)

80 (23.7%)

74 (21.1%)

76 (21.7%)

<0.001

  Stage 3 (30–59 mL/min/1.73 m2)

78 (97.5%)

73 (98.7%)

75 (98.7%)

0.9

  Stage 4 (15–29 mL/min/1.73 m2)

2 (2.5%)

1 (1.4%)

1 (1.3%)

0.8

  Stage 5 (<15 mL/min/1.73 m2)

0

0

0

0.9

Serum creatinine, μmol/L, median (IQR)

97 (80, 115)

106 (88, 124)

106 (88, 124)

<0.001c

Estimated glomerular filtration rate, median (IQR)

47.5 (41, 55)

53 (45, 55)

52 (47, 57)

<0.001c

  1. IQR interquartile range (25th, 75th percentile).
  2. cQuantile regression to compare medians.
  3. MDRD Modification of Diet in Renal Disease Study.
  4. CKD-EPI Chronic Kidney Disease Epidemiology Collaboration.