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Table 3 Logistic regression models for metformin use and association with chronic kidney disease (CKD) and demographic characteristics

From: Medication safety and chronic kidney disease in older adults prescribed metformin: a cross-sectional analysis

 

Age

Female

Weight

Non-Hispanic black

 

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Any CKDd

1.13 (1.08-1.19)

<0.001

2.51 (1.44-4.38)

0.001

0.99 (0.98-1.01)

0.32

0.41 (0.23-0.71)

0.001

CKD calculated by Cockcroft-Gaultd

1.16 (1.10-1.23)

<0.001

1.03 (0.52-2.04)

0.94

0.92 (0.90-0.95)

<0.001

0.76 (0.39-1.50)

0.43

CKD calculated by MDRDd

1.09 (1.04-1.14)

0.001

3.22 (1.70-6.12)

<0.001

1.02 (1.00-1.03)

0.01

0.33 (0.17-0.62)

0.001

CKD calculated by CKD-EPId

1.11 (1.05-1.16)

<0.001

3.44 (1.81-6.53)

<0.001

1.02 (1.01-1.03)

0.005

0.38 (0.20-0.71)

0.002

  1. MDRD Modification of Diet in Renal Disease Study.
  2. CKD-EPI Chronic Kidney Disease Epidemiology Collaboration.
  3. CKD defined as stage 3 or higher (<60 mL/min/1.73 m2) by either the Cockcroft-Gault, abbreviated MDRD or CKD-EPI equations.
  4. dMultivariable logistic regression model P < 0.001.
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BMC Nephrology

ISSN: 1471-2369

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