Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients: a retrospective observational study

Table 4 Interaction between acute kidney injury and proteinuria on the risk of mortality

	No proteinuria		Proteinuria
	N with/without outcome	OR (95% CI)	N with/without outcome	OR (95% CI)	OR for proteinuria within strata of AKI status
No AKI	52/152	1 (Reference)	89/109	2.39 (1.566–3.637)*	2.39 (1.566–3.637)*
AKI	231/179	3.77 (2.604–5.464)*	736/335	6.42 (4.569–9.026)*	1.70 (1.347–2.151)*
OR for AKI within strata of proteinuria status		3.77 (2.604–5.464)*		2.69 (1.977–3.663)*

Measure of interaction on additive scale: RERI (95% CI) = 1.26 (−0.153–2.556); AP (95% CI) = 0.20 (−0.230–0.356); SI (95% CI) = 1.30 (0.974–1.750).
*P < 0.001.
OR, odds ratio; CI, confidence interval; AKI, acute kidney injury; RERI, relative excess risk due to interaction; AP, attributable proportion; SI, synergy index.

ISSN: 1471-2369