Table 1 Baseline characteristics of the Framingham Offspring Study participants stratified by quartiles of serum B12
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
|---|---|---|---|---|---|
Characteristic | Mean/n/median | Mean/n/median | Mean/n/median | Mean/n/median | p-value* |
N | 741 | 741 | 742 | 741 | |
B12, mean, pg/ml (SD) | 243 (47) | 348 (25) | 444 (32) | 648 (153) | |
B12, range, pg/ml (IQR) | 50-306 | 307-393 | 394-502 | 503-1690 | |
Age, years (SD) | 58.7 (10.0) | 58.4 (9.9) | 58.5 (9.4) | 58.7 (9.6) | 0.92 |
Sex, n (%women) | 382 (51.6) | 359 (48.4) | 379 (51.1) | 458 (61.8) | 0.16 |
Diabetes, n, (%) | 64 (8.6) | 63 (8.5) | 81(10.9) | 73 (9.8) | 0.07 |
Systolic BP, mmHg (SD) | 128.1 (18.5) | 128.8 (19.5) | 128.8 (18.4) | 128.1 (19.1) | 0.81 |
Diastolic BP, mmHg (SD) | 75.6 (9.3) | 75.7 (9.9) | 75.7 (9.3) | 78.1 (9.3) | 0.81 |
Hypertension Treatment, n (%) | 207 (28.0) | 207 (27.9) | 206 (27.7) | 199 (26.9) | 0.98 |
Body Mass Index, kg/m2 (SD) | 28.3 (5.0) | 28.0 (4.9) | 28.2 (5.7) | 27.2 (5.0) | <0.001 |
HDLc, mg/dl (SD) | 50.2 (15.4) | 50.0 (16.1) | 51.1 (16.1) | 52.6 (16.9) | 0.17 |
Current Smoker, n (%) | 116 (15.7) | 119 (16.1) | 112 (15.1) | 103 (13.9) | 0.51 |
eGFR, ml/min/1.73 m2 (SD) | 85.1 (18.2) | 85.3 (19.1) | 84.6 (18.6) | 84.9 (19.5) | 0.68 |
RKF, n (%) | 87 (10.1) | 72 (8.4) | 78 (9.0) | 82 (9.5) | 0.91 |
UACR, mg/g (IQR) | 6.1 (2.7-13.5) | 5.9 (2.5-15.6) | 6.1 (2.9-14.9) | 7.6 (3.2-17.4) | 0.49 |
Microalbuminuria, n (%) | 115 (15.5) | 133 (17.9) | 131 (17.7) | 144 (19.4) | 0.1 |
Homocysteine, μmol/L (SD) | 11.2 (5.1) | 9.9 (3.5) | 9.2 (2.8) | 8.6 (3.0) | <0.001 |