Figure 5
Glomerular H-E staining scores in the kidney samples on day 4 (4-d) and weeks 3 (3-w) and 5 (5-w) after repeated injections of pCAG/DT-A/FuGENEâ„¢6 complex, pCAG/FuGENEâ„¢6 complex or mock injections [FuGENEâ„¢6 only or PBS(-) only]. At least 100 glomeruli in the H-E-stained sections were randomly chosen per kidney and the lesions were quantified. A total of 4 kidneys for each group were inspected. The glomerular lesions were graded from 0 to 2: score 0, normal; score 1, weak to mild change (exhibiting mild mesangial cell proliferation and mesangial matrix expansion); score 2, severe change (exhibiting lobular structure of glomeruli and adhesion of glomeruli to the inner surface of Bowman's capsule).