Figure 2

Dose-dependent effect of IP-10/CXCL10 and Mig/CXCL9 on proliferation of human MCIncubation of human MC for 24 hours with various concentrations of IP-10/CXCL10 and Mig/CXCL9 (10 ng/ml, 100 ng/ml, 250 ng/ml) induces proliferation of MC in a dose-dependent manner. Cell proliferation was analyzed with the MTT assay as described in Methods. Cells growing under standard conditions served as control. Changes in proliferative activity are given as relative values to the respective controls. Each bar represents a mean ± SEM of 5 parallel incubations for each condition. Statistically significant differences to the control are depicted with * = p < 0.05 and ** = p < 0.01, resp. Comparable results were obtained in three series of independent experiments.