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Table 4 Amino acid release from the isolated perfused hindlimb. P- values indicate significant differences in the comparison between sham- operated and nephrectomized animals, either without or with RU 38486 treatment. A: p- value for SHAM vs. SHAM + RU; B: p- value for BNX vs. BNX + RU; C: p- value for SHAM vs. BNX; D: p- value for SHAM + RU vs. BNX + RU.

From: Antiglucocorticoid RU38486 reduces net protein catabolism in experimental acute renal failure

  SHAM SHAM+RU BNX BNX+RU A: p-value B: p-value C: p-value D: p-value
Ala 13.26 10.08 15.61 13.23 <0.02 n.s <0.05 <0.05
Glu 15 13.69 17.39 15.37 n.s n.s <0.05 <0.05
Gly 7.56 7.11 6.53 5.26 n.s <0.005 n.s <0.001
Ser 3.27 2.75 3.12 2.6 n.s <0.025 n.s n.s
Thr 3.58 2.98 3.62 3.11 n.s ~0.05 n.s n.s
Val 2.2 1.49 2.32 1.7 <0.005 <0.001 n.s n.s
Leu 2.08 1.43 2.04 1.66 <0.005 ~0.05 n.s n.s
Ile 0.95 0.63 0.97 0.63 <0.025 <0.005 n.s n.s
Phe 1.78 1.23 2.29 2.02 <0.05 n.s <0.05 <0.001
Tyr 1.41 1.09 1.68 1.48 n.s ~0.05 n.s <0.01
Lys 6.53 5.08 6.91 5.54 <0.05 <0.005 n.s n.s
Arg 2.5 1.9 3.16 2.57 <0.05 <0.05 <0.02 <0.05
His 1.63 1.22 2.33 2.12 n.s n.s <0.025 <0.001
Glu 0.31 0.28 0.32 0.26 n.s n.s n.s n.s
Asn 1.49 1.05 1.7 1.57 n.s n.s n.s <0.02
Met 1.1 0.65 1.17 1.03 <0.02 n.s n.s <0.001
Trp 0.43 0.32 0.47 0.46 n.s n.s n.s <0.01