Table 4 Amino acid release from the isolated perfused hindlimb. P- values indicate significant differences in the comparison between sham- operated and nephrectomized animals, either without or with RU 38486 treatment. A: p- value for SHAM vs. SHAM + RU; B: p- value for BNX vs. BNX + RU; C: p- value for SHAM vs. BNX; D: p- value for SHAM + RU vs. BNX + RU.
From: Antiglucocorticoid RU38486 reduces net protein catabolism in experimental acute renal failure
| Â | SHAM | SHAM+RU | BNX | BNX+RU | A: p-value | B: p-value | C: p-value | D: p-value |
|---|---|---|---|---|---|---|---|---|
Ala | 13.26 | 10.08 | 15.61 | 13.23 | <0.02 | n.s | <0.05 | <0.05 |
Glu | 15 | 13.69 | 17.39 | 15.37 | n.s | n.s | <0.05 | <0.05 |
Gly | 7.56 | 7.11 | 6.53 | 5.26 | n.s | <0.005 | n.s | <0.001 |
Ser | 3.27 | 2.75 | 3.12 | 2.6 | n.s | <0.025 | n.s | n.s |
Thr | 3.58 | 2.98 | 3.62 | 3.11 | n.s | ~0.05 | n.s | n.s |
Val | 2.2 | 1.49 | 2.32 | 1.7 | <0.005 | <0.001 | n.s | n.s |
Leu | 2.08 | 1.43 | 2.04 | 1.66 | <0.005 | ~0.05 | n.s | n.s |
Ile | 0.95 | 0.63 | 0.97 | 0.63 | <0.025 | <0.005 | n.s | n.s |
Phe | 1.78 | 1.23 | 2.29 | 2.02 | <0.05 | n.s | <0.05 | <0.001 |
Tyr | 1.41 | 1.09 | 1.68 | 1.48 | n.s | ~0.05 | n.s | <0.01 |
Lys | 6.53 | 5.08 | 6.91 | 5.54 | <0.05 | <0.005 | n.s | n.s |
Arg | 2.5 | 1.9 | 3.16 | 2.57 | <0.05 | <0.05 | <0.02 | <0.05 |
His | 1.63 | 1.22 | 2.33 | 2.12 | n.s | n.s | <0.025 | <0.001 |
Glu | 0.31 | 0.28 | 0.32 | 0.26 | n.s | n.s | n.s | n.s |
Asn | 1.49 | 1.05 | 1.7 | 1.57 | n.s | n.s | n.s | <0.02 |
Met | 1.1 | 0.65 | 1.17 | 1.03 | <0.02 | n.s | n.s | <0.001 |
Trp | 0.43 | 0.32 | 0.47 | 0.46 | n.s | n.s | n.s | <0.01 |