Table 2 Number of cases and controls needed to detect a 2-fold risk (alpha 5%, 1-beta = 80%). Comparison of heavy analgesic use (top tertile in grams) vs. non use in the respective categories of analgesics. Important: the subcategories are not mutually exclusive and cannot be added up to 100%.
From: Case-control study on analgesics and nephropathy (SAN): protocol
| Â | Prevalence in controls (%) | Nb of cases | Nb of controls |
|---|---|---|---|
All analgesics (phenacetin-free) | 22.8 | 104 | 416 |
Phenacetin-containing | 2.5 | 616 | 2464 |
MONOS | Â | Â | Â |
Paracetamol | 5.3 | 308 | 1232 |
ASA | 15.7 | 129 | 516 |
Ibuprofen | 2.1 | 728 | 2912 |
Other monos | 5.0 | 324 | 1296 |
COMBIS | Â | Â | Â |
Paracetamol+caffeine | 0.1 | 14 670 | 58 680 |
Paracetamol+ASA | 0.9 | 1657 | 6628 |
Paracet+ASA+caffeine | 4.1 | 388 | 1552 |
Others+caffeine | 0.6 | 2470 | 9880 |
Other combis without caffeine | 3.5 | 449 | 1800 |
Other combis+caffeine | 3.3 | 475 | 1900 |
Combis with codeine or barbiturates | 1.9 | 654 | 2616 |