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Table 2 Number of cases and controls needed to detect a 2-fold risk (alpha 5%, 1-beta = 80%). Comparison of heavy analgesic use (top tertile in grams) vs. non use in the respective categories of analgesics. Important: the subcategories are not mutually exclusive and cannot be added up to 100%.

From: Case-control study on analgesics and nephropathy (SAN): protocol

  Prevalence in controls (%) Nb of cases Nb of controls
All analgesics (phenacetin-free) 22.8 104 416
Phenacetin-containing 2.5 616 2464
MONOS    
Paracetamol 5.3 308 1232
ASA 15.7 129 516
Ibuprofen 2.1 728 2912
Other monos 5.0 324 1296
COMBIS    
Paracetamol+caffeine 0.1 14 670 58 680
Paracetamol+ASA 0.9 1657 6628
Paracet+ASA+caffeine 4.1 388 1552
Others+caffeine 0.6 2470 9880
Other combis without caffeine 3.5 449 1800
Other combis+caffeine 3.3 475 1900
Combis with codeine or barbiturates 1.9 654 2616