Table 8 Differences in immunohistochemical findings between ANCA (+) and ANCA (+) patients
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
ANCA (+) N = 26 | ANCA (-) N = 8 | p | |
|---|---|---|---|
I. Glomeruli | |||
PCNA(+) cells | 36 ± 16 | 26 ± 16 | NS |
α-SMA(+)cells | 34 ± 15 | 32 ± 19 | NS |
Monocytes/macrophages | 15 ± 10 | 14 ± 10 | NS |
LFA-1β(+)cells | 15 ± 6 | 10 ± 4 | NS |
TGF-β1 expression | 1.14 ± 0.69 | 2.25 ± 0.96 | 0.05 |
ICAM-1 expression | 1.53 ± 0.64 | 2.25 ± 0.96 | NS(0.06) |
C5b-9 expression | 2.27 ± 0.96 | 2.25 ± 0.5 | NS |
II. Tubulointerstitium | |||
HLA-DR(+) cells | 1207 ± 831 | 736 ± 300 | NS |
PCNA(+)cells | 809 ± 170 | 581 ± 181 | 0.041 |
α-SMA(+)cells | 728 ± 260 | 556 ± 318 | NS |
Monocytes/macrophages | 570 ± 204 | 452 ± 156 | NS |
LFA-1β(+)cells | 485 ± 149 | 517 ± 86 | NS |
ICAM-1 in tubules | 34.2 ± 11.4 | 45.5 ± 12.5 | NS |
C5b-9 in tubules | 32,3 ± 9,7 | 32,7 ± 8.16 | NS |
TGF-β1 in interstitium | 1.73 ± 0.8 | 2 ± 1.41 | NS |
TGF-β1 in tubules | 1.87 ± 0.83 | 2.25 ± 0.96 | NS |
ICAM-1in vessels | 1,21 ± 0,42 | 1.0 ± 0.01 | NS |
C5b-9 in vessels | 1.06 ± 0.25 | 1.01 ± 0.09 | NS |