Routine serum creatinine measurements: how well do we perform?

BMC Nephrology

Table 2 eGFR calculations and subsequent CKD classification based on minimum and maximum serum creatinine results obtained for each pool

Pool, μmol/L		1		2		3		4		5
Pool, μmol/L		35		70		112		296		934
Min and max Scr, μmol/L		27	53	59	80	104	124	274	313	868	990
eGFR, ml/min/1.73 m ²	child 6y	158	80^a,b
	CKD stage	G1	G2
	man 18y			140	124	90^a,b	73	28	24	7	6
	CKD stage			G1	G1	G1	G2	G4	G4	G5	G5
	woman 18y			128	93	68	55^a,b	21	18	5	4
	CKD stage			G1	G1	G2	G3a	G4	G4	G5	G5
	man 65 y			101	89^a,b	65^a,b	52	20	17	5	4
	CKD stage			G1	G2	G2	G3a	G4	G4	G5	G5
	woman 65y			92^a,b	67	49^a,b	39	15	13^a,b	4	3
	CKD stage			G1	G2	G3a	G3b	G4	G5	G5	G5

The updated Schwartz formula was used for eGFR calculation in the 6 year old child with a length = 116.5 cm [8]. The CKP-EPI formula was used for eGFR calculations in adults [11] (see Methods section).
(Grade 1) Normal GFR: ≥90 mL/min/1.73 m², (Grade 2) Mild impairment: 60-89 mL/min/1.73 m², (Grade 3a) Mild to moderate impairment: 45-59 mL/min/1.73 m², (Grade 3b) Moderate to severe impairment: 30-44 mL/min/1.73 m², (Grade 4) Severe impairment: 15-29 mL/min/1.73 m² and (Grade 5) End stage renal disease: <15 mL/min/1.73 m². In the absence of kidney damage, Grade 1 and 2 cannot be considered as CKD, but Grade 3 is always considered as CKD.
^aIndicates cases for which eGFR calculated for the minimum and maximum serum creatinine values classify patients in different CKD stages.
^bIndicates cases for which the calculated CKD stage is different from the CKD stage obtained when the target value of the pool is used.

ISSN: 1471-2369