Skip to main content

Table 3 Adjusted hazard ratios for dialysis or dialysis-free death, by CKD stage

From: Variability in estimated glomerular filtration rate values is a risk factor in chronic kidney disease progression among patients with diabetes

CKD stage

Early stage 3

Late stage 3

Stage 4

 

Model 1

Model 2

Model 1

Model 2

Model 1

Model 2

 

AHR

95% CI

AHR

95% CI

AHR

95% CI

AHR

95% CI

AHR

95% CI

AHR

95% CI

  

Low

High

 

Low

High

 

Low

High

 

Low

High

 

Low

High

 

Low

High

Variables

                  

eGFR variability (SD)

1.076

1.071

1.080

1.072

1.067

1.076

1.080

1.074

1.085

1.076

1.069

1.082

1.076

1.063

1.089

1.073

1.061

1.085

eGFR mean

0.963

0.961

0.966

0.968

0.965

0.970

0.950

0.948

0.953

0.951

0.948

0.954

0.928

0.922

0.933

0.927

0.922

0.933

eGFR slope (ml/min/1.73 m2 per year; 10 unit decrease)

1.011

1.004

1.018

1.010

1.003

1.017

1.007

1.004

1.009

1.008

1.006

1.011

1.064

1.035

1.094

1.067

1.038

1.096

Age (in years)

                  

 45-54

   

0.83

0.63

1.08

   

0.93

0.73

1.19

   

0.91

0.66

1.25

 55-64

   

0.89

0.68

1.16

   

0.93

0.73

1.19

   

0.86

0.63

1.18

 65-74

   

1.17

0.90

1.51

   

0.98

0.77

1.24

   

0.85

0.62

1.15

 75-84

   

1.58

1.22

2.05

   

1.15

0.91

1.46

   

0.82

0.60

1.12

 85 and above

   

2.71

2.05

3.57

   

1.78

1.37

2.31

   

1.07

0.75

1.52

 <45 (reference)

   

1

     

1

     

1

  

Sex

                  

 Women

   

0.63

0.54

0.72

   

0.64

0.55

0.76

   

0.66

0.54

0.81

 Men (reference)

   

1

     

1

     

1

  

Race/ethnicity

                  

 African American

   

1.07

1.02

1.13

   

1.10

1.03

1.16

   

1.14

1.06

1.22

 Hispanic

   

0.96

0.85

1.09

   

0.91

0.79

1.05

   

0.93

0.79

1.10

 Others

   

0.82

0.70

0.96

   

0.95

0.81

1.11

   

1.05

0.87

1.27

 White (reference)

   

1

     

1

     

1

  

VHA priority status

                  

 Severely disabled

   

1.26

1.21

1.32

   

1.17

1.11

1.23

   

1.2

1.12

1.28

 Moderately disabled

   

0.96

0.91

1.01

   

0.93

0.87

0.98

   

1.03

0.95

1.12

 Co-pay required

   

0.79

0.74

0.84

   

0.86

0.8

0.93

   

0.92

0.83

1.02

 Poverty (reference)

   

1

     

1

     

1

  

Prior hospitalization

   

1.56

1.50

1.62

   

1.48

1.42

1.55

   

1.28

1.21

1.37

Cardiovascular conditions

   

1.52

1.45

1.59

   

1.38

1.31

1.46

   

1.21

1.13

1.30

Mental comorbidities

   

1.12

1.07

1.17

   

1.10

1.04

1.16

   

1.06

0.99

1.14

  1. CKD: Chronic Kidney Disease; Model 1: Containing eGFR variation (SD), mean, and slope variables; Model 2: Model 1 plus all other independent variables (age, sex, race/ethnicity, VHA priority status, presence of hospitalization, cardiovascular conditions, and mental comorbidities); AHR: Adjusted Hazard Ratio; CI: Confidence Interval; All variables except for eGFR SD, mean and slope variables (time-varying variables) were derived from the baseline period. The indicator of presence of non-cardiovascular conditions (Table 1) was not included in the modeling because about 99% of patients had the conditions; eGFR: estimated Glomerular Filtration Rate; SD: standard deviation; VHA: Veterans Health Administration. The 880 people in the missing category of VHA priority status (Table 1) was not included for this analysis; We rounded the estimates for eGFR SD, mean and slope to the third decimal place to allow differentiation between the AHR, and low and high limit of the 95% CIs.