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Table 3 Unadjusted and adjusted hazards for composite event outcome by PTH change group (quartile) for all patients and stratified by baseline PTH

From: Parathyroid hormone change after cinacalcet initiation and one-year clinical outcome risk: a retrospective cohort study

Composite event *

PTH change group

Unadjusted

Adjusted

All patients

HR (95% CI)

P

HR (95% CI)

P

No PTH reduction

1.07 (0.90-1.26)

0.5

1.11 (0.94-1.32)

0.2

Quartile 1

Referent

 

Referent

 

Quartile 2

1.04 (0.87-1.26)

0.7

1.01 (0.84-1.22)

0.9

Quartile 3

1.07 (0.89-1.29)

0.5

0.98 (0.81-1.18)

0.8

Quartile 4

1.09 (0.91-1.31)

0.4

0.96 (0.79-1.16)

0.6

Baseline PTH 300-600 pg/mL

No PTH reduction

1.10 (0.86-1.42)

0.5

1.14 (0.88-1.47)

0.3

Quartile 1

Referent

 

Referent

 

Quartile 2

1.13 (0.86-1.50)

0.4

1.10 (0.83-1.46)

0.5

Quartile 3

1.03 (0.77-1.37)

0.8

0.91 (0.68-1.22)

0.5

Quartile 4

1.13 (0.85-1.49)

0.4

0.98 (0.73-1.31)

0.9

Baseline PTH > 600 pg/mL

No PTH reduction

1.06 (0.85-1.34)

0.6

1.08 (0.86-1.37)

0.5

Quartile 1

Referent

 

Referent

 

Quartile 2

0.98 (0.77-1.26)

0.9

0.96 (0.75-1.24)

0.8

Quartile 3

1.12 (0.88-1.42)

0.4

1.0 (0.78-1.28)

1.0

Quartile 4

1.06 (0.84-1.35)

0.6

0.93 (0.73-1.20)

0.6

  1. Patients were grouped based on quartiles of PTH decrease from first cinacalcet prescription. Patients whose PTH levels increased or remained unchanged were assigned to “no PTH reduction” group.
  2. *Composite events include death, or hospitalization for stroke, congestive heart failure, or acute myocardial infarction.
  3. CI, confidence interval; HR, hazard ratio; PTH, parathyroid hormone.